dc.contributor.author | Keating, A. F. | |
dc.contributor.author | Davoren, P. | |
dc.contributor.author | Smith, T. J. | |
dc.contributor.author | Cairns, Michael T. | |
dc.date.accessioned | 2016-05-17T15:17:05Z | |
dc.date.available | 2016-05-17T15:17:05Z | |
dc.date.issued | 2007-05-25 | |
dc.identifier.citation | Keating, AF,Davoren, P,Smith, TJ,Ross, RP,Cairns, MT (2007) 'Bovine kappa-casein gene promoter haplotypes with potential implications for milk protein expression'. Journal Of Dairy Science, 90 :4092-4099. | en_IE |
dc.identifier.issn | 1525-3198 | |
dc.identifier.uri | http://hdl.handle.net/10379/5813 | |
dc.description | Journal article | en_IE |
dc.description.abstract | Genetic analysis of the kappa-casein gene (CSN3) promoter regions of 42 cattle representing 9 different breeds revealed that 2 distinct haplotypes (A and B) exist at this locus, differing from each other by single base changes at positions -514 (T/G), -426 (T/C), and -384 ( T/C), where haplotype A has bases T, T, and T and haplotype B has bases G, C, and C. The AA and AB haplotypes were found to occur at a higher frequency in the animals tested, with 69.0 and 21.4% being homozygous and heterozygous, respectively. The sequences that include these polymorphisms are potentially important in transcriptional regulation of the kappa-casein gene, because they contain putative sites for binding of many transcription factors. Linkage disequilibrium between the kappa-casein promoter haplotype and either one of the 2 major kappa-casein coding sequence haplotypes was not evident. The A allele is dominant in all groups (dairy, beef, and dual purpose) with an allele frequency of 80% and is higher among high-yielding dairy animals (88.9%) than among beef animals (75%). The AB haplotype is comparatively rare in the dairy cattle (11.1%) compared with both beef and dual-purpose animals. The BB haplotype, though rare overall (9.5%), is much higher in dual-purpose animals (18.8%) than dairy (5.6%) animals. In contrast, the B allele is much more representative of the kappa-casein promoters from other ruminants. | en_IE |
dc.description.sponsorship | Enterprise Ireland; Teagasc Walsh fellowship | en_IE |
dc.format | application/pdf | en_IE |
dc.language.iso | en | en_IE |
dc.publisher | Elsevier ScienceDirect | en_IE |
dc.relation.ispartof | Journal Of Dairy Science | en |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Ireland | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ | |
dc.subject | Kappa-casein | en_IE |
dc.subject | Promoter haplotype | en_IE |
dc.subject | Expression study | en_IE |
dc.title | Bovine kappa-casein gene promoter haplotypes with potential implications for milk protein expression | en_IE |
dc.type | Article | en_IE |
dc.date.updated | 2016-05-17T12:04:35Z | |
dc.identifier.doi | 10.3168/jds.2006-687 | |
dc.local.publishedsource | http://dx.doi.org/10.3168/jds.2006-687 | en_IE |
dc.description.peer-reviewed | peer-reviewed | |
dc.contributor.funder | |~| | |
dc.internal.rssid | 1342612 | |
dc.local.contact | Michael Cairns, Glycoscience Group, Ncbes, Biomedical Sciences, Dangan, Newcastle Rd. 2094 Email: michael.cairns@nuigalway.ie | |
dc.local.copyrightchecked | Yes | |
dc.local.version | ACCEPTED | |
nui.item.downloads | 250 | |