Browsing Regenerative Medicine Institute (Scholarly Articles) by Author "http://dx.doi.org/10.13039/100011102"
Now showing items 1-9 of 9
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Anti-donor antibody induction following intramuscular injections of allogeneic mesenchymal stromal cells
Alagesan, Senthilkumar; Sanz‐Nogués, Clara; Chen, Xizhe; Creane, Michael; Ritter, Thomas; Ceredig, Rhodri; O'Brien, Timothy; Griffin, Matthew D. (Wiley, 2018-02-15)Allogeneic mesenchymal stromal cells (allo-MSC) are a promising "off-the-shelf" therapy with anti-inflammatory and pro-repair properties. This study investigated humoral immune responses to intramuscular (IM) injections ... -
Biodistribution and retention of locally administered human mesenchymal stromal cells: Quantitative polymerase chain reaction–based detection of human DNA in murine organs
Creane, Michael; Howard, Linda; O'Brien, Timothy; Coleman, Cynthia M. (Elsevier, 2017-01-12)Background. Determining the distributive fate and retention of a cell therapy product after administration is an essential part of characterizing it's biosafety profile. Therefore, regulatory guidelines stipulate that ... -
Current good manufacturing practice considerations for mesenchymal stromal cells as therapeutic agents
Sanz-Nogués, Clara; O'Brien, Timothy (Elsevier, 2021-05-05)Producing human mesenchymal stromal cells (MSCs) for clinical use requires adherence to current good manufacturing practice (cGMP) standards. This is necessary for ensuring standardization and reproducibility through the ... -
Editorial: Innovative biologics and drugs to target renal inflammation
Griffin, Matthew D.; Swaminathan, Sundararaman (Frontiers Media, 2020-02-06)[No abstract available] -
Effect of sodium glucose co-transporter-2 inhibition on the Aldosterone/Renin Ratio in Type 2 Diabetes Mellitus
Griffin, Tomás P.; Islam, Md Nahidul; Blake, Liam; Bell, Marcia; Griffin, Matthew D.; O’Shea, Paula M. (Thieme Publishing, 2018-12-06)The aldosterone to renin ratio (ARR) is recommended for case detection of primary aldosteronism (PA). Several factors including medications can undermine its diagnostic accuracy. The objective was to explore the effect of ... -
Effects of mesenchymal stromal cells on regulatory T cells: Current understanding and clinical relevance
Negi, Neema; Griffin, Matthew D. (AlphaMed Press and Wiley, 2020-01-29)The immunomodulatory potential of mesenchymal stromal cells (MSCs) and regulatory T cells (T-reg) is well recognized by translational scientists in the field of regenerative medicine and cellular therapies. A wide range ... -
Human monocyte subset distinctions and function: Insights from gene expression analysis
Cormican, Sarah; Griffin, Matthew D. (Frontiers Media, 2020-06-04)Monocytes are a highly plastic innate immune cell population that displays significant heterogeneity within the circulation. Distinct patterns of surface marker expression have become accepted as a basis for distinguishing ... -
Progress toward the clinical application of mesenchymal stromal cells and other disease-modulating regenerative therapies
Hickson, LaTonya J.; Herrmann, Sandra M.; McNicholas, Bairbre A.; Griffin, Matthew D. (American Society of Nephrology, 2021-01-27)Drawing from basic knowledge of stem cell biology, embryonic development, wound healing and aging, regenerative medicine seeks to develop therapeutic strategies that complement or replace conventional treatments by actively ... -
The secretome derived from mesenchymal stromal cells cultured in a xeno-free medium promotes human cartilage recovery in vitro
Palama, Maria Elisabetta Federica; Shaw, Georgina Margaret; Carluccio, Simonetta; Reverberi, Daniele; Sercia, Laura; Persano, Luana; Pisignano, Dario; Cortese, Katia; Barry, Francis Peter; Murphy, Josephine Mary; Gentili, Chiara (Frontiers Media, 2020-02-14)Osteoarthritis (OA) is a disabling joint disorder causing articular cartilage degeneration. Currently, the treatments are mainly aimed to pain and symptoms relief, rather than disease amelioration. Human bone marrow stromal ...