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Diversity and bioactivity of fungi associated with the marine sea cucumber Holothuria poli: disclosing the strains potential for biomedical applications
(Society for Applied Microbiology (SfAM), 2020-04-10)
Aims: Identification of the mycobiota associated to the marine echinoderm Holothuria poli and investigation of cytotoxic and pro-osteogenic potential of isolated strains.
Methods and results: Fungal strains were isolated ...
Applicability of FTIR-ATR method to measure carbonyls in blood plasma after physical and mental stress
(Hindawi, 2019-03-26)
Introduction. Oxidative stress is a state of imbalance between the production of reactive oxygen species and antioxidant defenses. It results in the oxidation of all cellular elements and, to a large extent, proteins, ...
Fasciola hepatica serine protease inhibitor family (serpins): Purposely crafted for regulating host proteases
(Public Library of Science, 2020-08-06)
Serine protease inhibitors (serpins) regulate proteolytic events within diverse biological processes, including digestion, coagulation, inflammation and immune responses. The presence of serpins in Fasciola hepatica ...
A novel high-throughput screening platform identifies itaconate derivatives from marine Penicillium antarcticum as inhibitors of mesenchymal stem cell differentiation
(MDPI, 2020-04-05)
Worldwide diffused diseases such as osteoarthritis, atherosclerosis or chronic kidney
disease are associated with a tissue calcification process which may involve unexpected local stem cell differentiation. Current ...
Biological applications of knowledge graph embedding models
(Oxford University Press (OUP), 2020-02-17)
Complex biological systems are traditionally modelled as graphs of interconnected biological entities. These graphs, i.e. biological knowledge graphs, are then processed using graph exploratory approaches to perform different ...
The secretome derived from mesenchymal stromal cells cultured in a xeno-free medium promotes human cartilage recovery in vitro
(Frontiers Media, 2020-02-14)
Osteoarthritis (OA) is a disabling joint disorder causing articular cartilage degeneration. Currently, the treatments are mainly aimed to pain and symptoms relief, rather than disease amelioration. Human bone marrow stromal ...
Therapeutic potential of intranasal photobiomodulation therapy for neurological and neuropsychiatric disorders: a narrative review.
(De Gruyter, 2019-12-09)
The application of photobiomodulation therapy (PBMT) for neuronal stimulation is studied in different animal models and in humans, and has shown to improve cerebral metabolic activity and blood flow, and provide neuroprotection ...
The collagen suprafamily: From biosynthesis to advanced biomaterial development
(Wiley, 2018-08-20)
Collagen is the oldest and most abundant extracellular matrix protein that has found many applications in food, cosmetic, pharmaceutical, and biomedical industries. First, an overview of the family of collagens and their ...
TGF-ß1-Licensed Murine MSCs show superior therapeutic efficacy in modulating corneal allograft immune rejection In Vivo
(Elsevier, 2020-05-29)
Mesenchymal stromal cells (MSCs) are a promising therapeutic option for multiple immune diseases/disorders; however, efficacy of MSC treatments can vary significantly. We present a novel licensing strategy to improve the ...
Conceptualising coping and resilience in the context of socio-political and economic change: Generational perspectives from Slovenia
(Routledge, 2020-06-09)
The significance of a wider social context in building youth resilience has recently been recognised, with the suggestion that resilience research requires a move from individual-level experience to wider social practices, ...