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Evaluation of the early in vivo response of a functionally graded macroporous scaffold in an osteochondral defect in a rabbit model
(Springer Verlag, 2015-10-05)
Cartilage tissue engineering is a multifactorial problem requiring a wide range of material property requirements from provision of biological cues to facilitation of mechanical support in load-bearing diarthrodial joints. ...
Endothelial nitric oxide synthase induces heat shock protein HSPA6 (HSP70B ) in human arterial smooth muscle cells
(Elsevier, 2015-12-01)
Endothelial nitric oxide synthase (eNOS) is the major source of nitric oxide (NO) production
in blood vessels. One of the pleitropic functions of eNOS derived NO is to inhibit vascular
smooth muscle cell proliferation ...
International law, literature and interdisciplinarity
(Taylor & Francis, 2015-07-03)
This article analyses the relationship between international law and literature from the point of view of its form of expression. Using insights from Deleuze and Guattari's analysis of Kafka's oeuvre as a ‘minor literature’, ...
Rethinking human rights and culture through female genital surgeries
(Johns Hopkins University Press, 2015-02)
The article revisits the relationship between culture and human rights through the analysis of one traditionally condemned cultural practice known in human rights law as female genital mutilation. The analysis draws on ...
Evaluation of cartilage repair by mesenchymal stem cells seeded on a PEOT/PBT scaffold in an osteochondral defect
(Springer Verlag, 2015-01-15)
The main objective of this study was to evaluate the effectiveness of a mesenchymal stem cell (MSC)-seeded polyethylene-oxide-terephthalate/polybutylene-terephthalate (PEOT/PBT) scaffold for cartilage tissue repair in an ...
Development of a rapid recombinase polymerase amplification assay for the detection of Streptococcus pneumoniae in whole blood
(BioMed Central, 2015-10-29)
Background: Streptococcus pneumoniae is an important cause of microbial disease in humans. The introduction of multivalent vaccines has coincided with a dramatic decrease in the number of pneumococcal-related deaths. In ...
Alignment-free clustering of transcription factor binding motifs using a genetic-k-medoids approach
(BioMed Central, 2015-01-28)
Background: Familial binding profiles (FBPs) represent the average binding specificity for a group of structurally related DNA-binding proteins. The construction of such profiles allows the classification of novel motifs ...
Effects of combined progesterone and beta-estradiol treatment on the transcriptome of cultured human myometrial smooth muscle cells
(American Physiological Society, 2015)
A transcriptomic analysis of cultured human uterine smooth muscle cells (hUtSMCs) was performed in order to examine gene expression profiles in smooth muscle in an environment containing the two major steroid hormones that ...
Hyaluronic acid based hydrogels attenuate inflammatory receptors and neurotrophins in interleukin-1 beta induced inflammation model of nucleus pulposus cells
(American Chemical Society, 2015-04-14)
Inflammation plays an important role in symptomatic intervertebral disc degeneration and is associated with the production of neurotrophins in sensitizing innervation into the disc. The use of high molecular weight (HMw) ...
Synthesis of polymer-silica hybrid microparticles with defined geometry using surface initiated atom transfer radical polymerization
(Royal Society of Chemistry, 2015)
Nanostructured polymer/silica hybrid materials have gained attention as they combine the advantageous properties of organic and inorganic materials in one entity. Herein, we report incorporation of chloromethyl moieties ...