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Differential release of high mannose structural isoforms by fungal and bacterial endo-β-N-acetylglucosaminidases
(Royal Society of Chemistry, 2012-02-28)
Endo-beta-N-acetylglucosaminidases (ENGases) are widely used to remove N-linked oligosaccharides from glycoproteins for glycomic and proteomic studies and biopharmaceutical processes. Although several ENGases are widely ...
Low resistance, highly corrugated structures based on poly(3,4-ethylenedioxythiophene) doped with a d-glucopyranoside-derived ionic liquid
(Elsevier, 2019-12-02)
Conjugated polymers have gained significant interest as highly conducting organic materials with versatile surface morphology. In this study, we demonstrate that the electrodeposition of poly(3,4-ethylenedioxythiophene), ...
Schistosoma mansoni immunomodulatory molecule Sm16/SPO-1/SmSLP is a member of the trematode-specific helminth defence molecules (HDMs)
(Public Library of Science, 2020-07-09)
Sm16, also known as SPO-1 and SmSLP, is a low molecular weight protein (~16kDa) secreted by the digenean trematode parasite Schistosoma mansoni, one of the main causative agents of human schistosomiasis. The molecule is ...
Joint academic and industrial efforts towards innovative and efficient solutions for clinical needs
(Springer Verlag, 2018-07-31)
The 4th Translational Research Symposium (TRS) was organised at the annual meeting of the European Society for Biomaterials (ESB) 2017, Athens, Greece, with a focus on ‘Academia—Industry Clusters of Research for Innovation ...
The role of the natural aquatic environment in the dissemination of extended spectrum beta-lactamase and carbapenemase encoding genes: A scoping review
(Elsevier, 2020-05-07)
The natural aquatic environment is a significant contributor to the development and circulation of clinically significant antibiotic resistance genes (ARGs). The potential for the aquatic environment to act as a reservoir ...
Recent advances in host–guest self‐assembled cyclodextrin carriers: Implications for responsive drug delivery and biomedical engineering
(Wiley, 2020-02-05)
This Review is an overview of the unique characteristics of cyclodextrin in forming an inclusion complex via host guest noncovalent interactions. The modification of cyclodextrin advances its application as a pharmaceutical ...
Biophysics rules the cell culture but has yet to reach the clinic: Why is that?
(Lippincott, Williams & Wilkins, 2017-07)
Musculoskeletal injuries are the leading cause of physical disability worldwide, with associated annual direct and indirect healthcare expenditure in excess of $874 billion in the United States alone.1 Current treatments ...
Local pharmacological induction of angiogenesis: drugs for cells and cells as drugs
(Elsevier, 2019-06-19)
The past decades have seen significant advances in pro-angiogenic strategies based on delivery of molecules and cells for conditions such as coronary artery disease, critical limb ischemia and stroke. Currently, three major ...
In vitro attenuation of astrocyte activation and neuroinflammation through ibuprofen-doping of poly(3,4-ethylenedioxypyrrole) formulations
(Elsevier, 2020-04-08)
Neuroinflammation is often associated with poor functional recovery and may contribute to or initiate the development of severe neurological disorders, such as epilepsy, Parkinson's disease or Alzheimer's disease. Ibuprofen ...
Campylobacter jejuni strain discrimination and temperature-dependent glycome expression profiling by lectin microarray
(Elsevier, 2014-02-12)
Gram-negative Campylobacter jejuni is the leading cause of bacterial gastroenteritis in humans worldwide and the most frequently identified infectious trigger in patients developing Guillain-Barré syndrome (GBS). While ...