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dc.contributor.authorShantier, Mohamed
dc.contributor.authorMartin, William P.
dc.contributor.authorSingh, Rajneet
dc.contributor.authorMcDermott, Paul
dc.contributor.authorGallen, Rory
dc.contributor.authorSuleiman, Sami
dc.contributor.authorReddan, Donal N.
dc.contributor.authorGiblin, Louise
dc.contributor.authorLappin, David
dc.contributor.authorO’Meara, Yvonne M.
dc.contributor.authorGriffin, Matthew D.
dc.identifier.citationShantier, Mohamed, Martin, William P., Singh, Rajneet, McDermott, Paul, Gallen, Rory, Suleiman, Sami, Reddan, Donal N., Giblin, Louise, Lappin, David, O’Meara, Yvonne M., Griffin, Matthew D. (2018). Increased weight gain during the long interdialytic period Is associated with minor effects on blood pressure control in clinically stable in-centre haemodialysis patients. Nephron, 141, 87-97, doi:10.1159/000494221en_IE
dc.description.abstractBackground/Aims: Three-day-a-week chronic haemodialysis (cHD) involves 1 long (72 h) and 2 short (48 h) inter-dialytic periods (IDPs), We aimed to determine whether BP control following the long IDP is inferior to the short IDPs. Methods: All pre- and post-dialysis BP and weight measurements over a 4-week period were retrospectively analyzed among 135 clinically stable cHD patients at 2 academic centres with comparisons between measurements recorded following short and long IDPs. Subsequently, 23 clinically stable cHD patients underwent 24-h ambulatory blood pressure monitoring (ABPM) during the final day/night cycle of the long IDP and 1 short IDP within the same week. Results: In combined and separate analyses of the 2 retrospective cohorts, pre-dialysis BP parameters were not different following long and short IDPs despite greater inter-dialytic weight gain (IDWG) during the long IDP. Subgroup analyses of the total cohort showed no evidence for inferior BP control during the long IDP among those with high %IDWG. In the ABPM study, nocturnal hypertension and loss of nocturnal dipping were frequent, Furthermore, daytime systolic blood pressure (SBP) and pulse pressure were modestly higher during the last day/night cycle of the long compared with short IDP, Conclusion: In stable cHD patients, the greater IDWG that occurred during the long IDP was not associated with overtly inferior BP control as reflected in pre-dialysis BP measurements. However, modestly higher daytime SBP was evident towards the end of the long IDP by 24 h ABPM. Thus, while fluid gain has well-documented associations with hypertension and adverse cardiovascular outcomes, the excess IDWG that occurs during the long IDP exerts relatively minor effects on BP control in patients on well-established dialysis regimens that are better identified by ambulatory monitoring. (C) 2018 S. Karger AG, Baselen_IE
dc.publisherKarger Publishersen_IE
dc.subjectEnd-stage renal diseaseen_IE
dc.subjectBlood pressureen_IE
dc.subjectFluid volumeen_IE
dc.subjectInter-dialytic perioden_IE
dc.subjectDialysis patienten_IE
dc.subjectAmbulatory blood pressure monitoringen_IE
dc.subjectAntihypertensive therapyen_IE
dc.titleIncreased weight gain during the long interdialytic period Is associated with minor effects on blood pressure control in clinically stable in-centre haemodialysis patientsen_IE
dc.local.contactMatthew Dallas Griffin, Remedi, Biomedical Sciences Buil, Corrib Village, Dangan, Nui Galway. 5436 Email:

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