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An optical investigation into post compression aerodynamics in a dual opposed piston rapid compression machine
(NUI Galway, 2020-02-07)
Experimental chemical kineticists use rapid compression machines (RCMs) to verify models of global reactivity of fuels in as an ideal environment as possible, similar to those experienced in internal combustion engines. ...
Experimental studies of simple hydrocarbons in a shock tube
(NUI Galway, 2020-09-24)
Chemical kinetic models are needed to simulate fuel chemistry in combustion devices and to aid
in the development of new designs to reduce harmful emissions and maximize combustor performance.
However, these models need ...
Anisotropy Resolved Multidimensional Emission Spectroscopy (ARMES) for the analysis of Immunoglobulin G (IgG) type proteins
(NUI Galway, 2020-10-02)
Immunoglobulin G (IgG) is the main antibody used in the biopharmaceutical industry for therapeutic purposes. Monoclonal antibodies (mAb) are growing in the marked due to its high specificity and safety. Physical and ...
Anisotropy Resolved Multidimensional Emission Spectroscopy (ARMES) as a tool for biophysical analysis
(NUI Galway, 2021-10)
The development of analytical tools for the biophysical analysis of biological
samples is an area of tremendous application and potential. In this work the use and
efficacy of an analytical methodology, known as anisotropy ...
Advances in ruthenium-based light harvesting materials and photocatalysis: From molecular photosensitizers to photoactive frameworks
(NUI Galway, 2022-04-08)
The presented manuscript deals with the areas of light harvesting and photocatalysis in solar chemistry. The work presented is divided into several sections, beginning with an introductory chapter on the main topics involved ...
Crystal growth and design of multicomponent pharmaceuticals
(NUI Galway, 2022-08-30)
Cocrystallisation and salt formation is a widely studied method of optimising the action of
Active Pharmaceutical Ingredients (APIs) without chemical modification of the parent
compound. Careful selection of suitable ...
Irelands’ hidden pharmacy: Marine biodiscovery applied to deep-sea sponges and corals
(NUI Galway, 2022-06-08)
Natural products have provided over 60% of our medicines to date, but their search has focused on easy to access habitats, leaving the marine realm underexplored. The deep-sea, which is the world’s largest biome and ...
Small–molecule reagents and building–blocks for protein materials and bioconjugation
(NUI Galway, 2023-04-18)
The molecular and functional diversification conferred by posttranslational modification
(PTM) of proteins is a common target and source of inspiration for chemical biologists.
For example, the formylglycine-generating ...
Mediated glucose biosensors for application in continuous glucose monitoring
(NUI Galway, 2023-04-19)
Diabetes affects 1 in 11 people globally and requires monitoring of blood glucose
levels as a part of its treatment. Initial blood glucose monitoring devices involved
finger prick testing at regular intervals daily, a ...
Theoretical, experimental and modelling studies of the reactions of hydrogen atoms with C2 – C5 alkenes and cyclisation reactions of hydroperoxyl-alkyl radicals forming cyclic ethers and hydroxyl radicals
(NUI Galway, 2021-06-22)
This thesis presents a hierarchical study of the reactions of Ḣ atom addition to and abstraction from both linear and branched C2 – C5 alkenes. The subsequent C–C and C–H β-scission reactions and H-atom transfer reactions ...