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Crystal growth and design of multicomponent pharmaceuticals
(NUI Galway, 2022-08-30)
Cocrystallisation and salt formation is a widely studied method of optimising the action of
Active Pharmaceutical Ingredients (APIs) without chemical modification of the parent
compound. Careful selection of suitable ...
Irelands’ hidden pharmacy: Marine biodiscovery applied to deep-sea sponges and corals
(NUI Galway, 2022-06-08)
Natural products have provided over 60% of our medicines to date, but their search has focused on easy to access habitats, leaving the marine realm underexplored. The deep-sea, which is the world’s largest biome and ...
Bioprocess monitoring using Polarised Multidimensional Fluorescence (pMDF) spectroscopy
(NUI Galway, 2022-06-15)
Bioprocess monitoring is essential for biopharmaceutical manufacturing as it helps to ensure the required quality of the therapeutic proteins and maximise the productivity of the bioprocess as per Quality-by-Design (QbD) ...
Exploring the chemical diversity of marine sponges from Futuna Islands in the Pacific ocean
(NUI Galway, 2022-06-15)
Marine biodiversity is still unknown in underexplored regions of the Ocean. Sponges, and their associated microbiome, living in the precious marine ecosystems are known to produce intricate chemical scaffolds ...
Regulation and evolution of the σB stress sensing pathway in Listeria monocytogenes: impact on stress tolerance, fitness and virulence
(NUI Galway, 2022-06-15)
The Gram-positive bacterium Listeria monocytogenes is the aetiological agent
of listeriosis, a high death rate infection in susceptible groups, caused by the
ingestion of contaminated food. L. monocytogenes is a highly ...