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Towards an additive manufactured macroencapsulation device for islet cell replacement therapy
(NUI Galway, 2020-07-28)
Islet encapsulation devices can induce a Foreign Body Response (FBR) and the formation of a hardened avascular fibrotic capsule. This FBR is heightened when the device features a smooth surface as fibrous tissue is unable ...
Environmental and genetic risk factors in Autism Spectrum Disorder: a stereological study
(NUI Galway, 2020-07-15)
Autism spectrum disorders (ASD), include a group of heterogeneous
neurodevelopmental disorders (NDDs) characterized by impaired social interaction,
and communication with restricted patterns of behaviour. The aetiology ...
Medical devices for the minimally invasive delivery of therapeutic cargo for the prevention of heart failure
(NUI Galway, 2020-11-10)
Therapeutic advances are increasing the number of patients that survive cardiac disease
such as a myocardial infarction, however, current treatments do not fully stop the
development of heart failure. Advanced therapeutic ...
The neural network basis of cognitive impairment in bipolar disorder
(NUI Galway, 2020-01-22)
Background: Despite well-documented cognitive deficits that contribute to poorer quality of life in bipolar disorder (BD) and evidence of altered topology and connectivity within neural networks, little work has been done ...
Glycosylation in the injured and regenerating spinal cord, and the influence of biomaterial treatment
(NUI Galway, 2020-02-04)
Traumatic spinal cord injury (SCI) results in disruption of tissue integrity leading to a loss of function. There has been minimal success in treating these injuries clinically, due to the inhibitory environment which ...