Browsing University of Galway Theses (PhD Theses) by Subject "Synthesis"
Now showing items 1-3 of 3
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The anomerisation of glycosidic linkages
(2014-04-07)This thesis deals with the anomerisation of glycosidic linkages using TiCl4 and SnCl4. Methods involving the Lewis acid induced anomerisations of glycosides have been published over the past decade, however this methodology ... -
Cycloaddition reactions of imidazolium and phthalazinium dicyanomethanide 1,3-dipoles: synthesis, mechanism and the effect of water
(2017-09-28)The cycloaddition reactions of imidazolium-3-dicyanomethanide 1,3-dipoles with electron poor alkene and alkyne dipolarophiles were explored. The reactions of these azolium 1,3-dipoles with alkyne dipolarophiles generated ... -
Investigation of various ligand design approaches and synthesis of diverse heterocyclic bioactive compounds
(NUI Galway, 2019-09-27)Structure-based design and ligand-based design are one of the most common approaches used to develop new inhibitors against druggable protein targets in various human disorders. Mcl-1 is a protein belongs to Bcl-2 family ...