Browsing University of Galway Theses (PhD Theses) by Subject "Inflammation"
Now showing items 1-17 of 17
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Blood biomarker monitoring in professional soccer: Longitudinal analysis of inflammation in English Premier League players
(NUI Galway, 2021-09-06)The high intensity demands of elite soccer predispose players to recurrent episodes of acute inflammation, and during periods of frequent match play recovery time may not be adequate for the resolution of the inflammatory ... -
CDC7 kinase promotes replication DNA double-strand breaks upon replication fork stalling and its inhibition causes an inflammatory response and senescence
(NUI Galway, 2022-12-08)CDC7 is an essential serine-threonine kinase that has an important role in the initiation of DNA replication. CDC7 phosphorylates several sites of the MCM helicase complex allowing recruitment of CDC45, among other factors, ... -
Cognitive functioning in schizophrenia: Characterising the effects of common genetic variation, brain structure, inflammation, and early life adversity
(NUI Galway, 2024-03-08)Schizophrenia is a complex, highly polygenic neuropsychiatric disorder. Individuals with schizophrenia experience neurocognitive and social cognitive deficits that can impact their ability to work, live independently, ... -
Elastin-like polypeptide mediated proangiogenic and anti-inflammatory gene therapy for critical limb ischemia
(2014-12-17)Critical limb ischemia is a major clinical problem. Despite rigorous treatment regimes, there has been modest success in reducing the rate of amputations in these patients. Reduced level of blood flow and enhanced inflammation ... -
Endocannabinoid modulation of TLR3-induced neuroinflammation
(2017-10-06)Toll-like receptors (TLRs) play a key role in the recognition and activation of the innate immune system in response to infection. However, aberrant TLR activation has been implicated in predisposing to, and exacerbating, ... -
Endocannabinoid modulation of TLR4-induced neuroinflammation: implications for autism spectrum disorders
(2014-07-07)Neuroinflammation is a key component of various neurological diseases including Alzheimer's disease, Parkinson's disease, multiple sclerosis and psychiatric and neurodevelopmental disorders such as depression and autism. ... -
Enhancing the immunomodulatory efficacy of allogeneic mesenchymal stromal cells through pro-inflammatory cytokine licensing
(NUI Galway, 2024-04-17)The therapeutic efficacy and immunomodulatory potential of mesenchymal stromal cells (MSCs) is well established. MSCs have been employed as cellular therapies to treat various inflammatory-based conditions. MSC potency can ... -
Environmental and genetic risk factors in Autism Spectrum Disorder: a stereological study
(NUI Galway, 2020-07-15)Autism spectrum disorders (ASD), include a group of heterogeneous neurodevelopmental disorders (NDDs) characterized by impaired social interaction, and communication with restricted patterns of behaviour. The aetiology ... -
Epigenetic regulation of NOD-like receptor activity and expression
(NUI Galway, 2018-11-19)NOD-like receptors (NLRs) are a family of intracellular pathogen recognition receptors involved in the innate immune response. NOD1 and NOD2 are the best characterised members of this family, and so are the focus of this ... -
Feasibility of mesenchmyal stem cells as modulators of inflammation and as a cellular model to study cartilage damage in osteoarthritis
(NUI Galway, 2020-04-10)Osteoarthritis (OA) is the most common degenerative condition affecting whole joints and causing pain and cartilage degeneration, particularly in the elderly population. Inflammation of the synovium is now recognised as ... -
Immunomodulation by interleukin-10 overexpressing mesenchymal stem cells for cartilage repair in osteoarthritis
(2015-03-06)Although osteoarthritis (OA) is typically characterised by the loss or damage to articular cartilage, inflammation of the synovial membrane is now recognised as a prevalent feature believed to contribute to both symptoms ... -
The influence of collagen isolation, cross-linking and sterilisation on macrophage response
(2018-03-07)Collagen-based devices are frequently associated with foreign body response. Although several pre- (e.g. species, state of animal, tissue, isolation protocol) and post- (e.g. cross-linking, scaffold architecture, sterilisation) ... -
Intra-Renal Inflammation in Obesity and Type 2 Diabetes Mellitus
(2013-09-30)Introduction: Unhealthy diet and sedentary lifestyle, lead to the constellation of obesity, hyperinsulinaemia and hyperlipidaemia that are risk factors for both chronic kidney disease and type 2 Diabetes mellitus. Renal ... -
Investigating the effect of anti-inflammatory hyaluronic acid towards regenerating the annulus fibrosus
(2017-05-11)Neck and low-back pain are major causes of disability leading to a serious socio-economic burden worldwide. The pathology is strongly correlated with the intervertebral disc degeneration (IVD). Disc degenerative disease ... -
A multi-modal collagen nucleic acid delivery system for the modulation of inflammation and promotion of angiogenesis
(2014-12-15)Tissue engineered organs and implants hold promise for the replacement of damaged and diseased organs. However, the foreign body response (FBR) is a major obstacle that compromises the function of tissue engineered constructs, ... -
The role of IRE1α in the regulation of cytokine production
(NUI Galway, 2020-04-16)Inositol-requiring enzyme 1 (IRE1), a key mediator of the unfolded protein response (UPR), has emerging roles within innate immunity and cancer progression. Here we examine how IRE1 signalling influences the production ... -
Stress-induced exacerbation of LPS/GalN liver injury
(NUI Galway, 2018-08-21)Stress is a key regulator of homeostasis in the body. However, aberrant activation of the stress response has been implicated in predisposing to, and exacerbating processes that underlie a variety of pathological conditions ...