Browsing University of Galway Theses (PhD Theses) by Subject "Glycobiology"
Now showing items 1-7 of 7
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Computationally Guided Directed Evolution of O-GlcNAcase into a Reagent Specific for [beta]-O-GlcNAc
(2013-12-13)Protein glycosylation with O-linked N-Acetylglucosamine (O-GlcNAc) is a post-translational modification of serine and threonine residues in nucleocytoplasmic proteins. Alterations in the glycosylation pattern of O-GlcNAc ... -
Development and Application of a Computational Method for Determining the Specificity of Glycan-binding Proteins
(2013-09-25)Changes in cell-surface glycan patterns are markers for the presence of many different disease and cancer types, offering a relatively untapped niche for glycan-targeting reagents and therapeutics in diagnosis and treatment. ... -
Elastin-like recombinamers-based hydrogel modulates the post-ischemic remodelling in a clinically-relevant model of myocardial infarction
(NUI Galway, 2019-04-17)Myocardial infarction (MI) belongs to the family of cardiovascular diseases and represents the primary cause of worldwide mortality. Despite the promising results achieved in both small and large animal studies, recent ... -
Fractionation of whey protein glycosylation and assessment of prebiotic and immunomodulation bioactivities for valorisation
(NUI Galway, 2021-03-15)Functional foods are defined as food components that, in addition to their nutritional value, improve human health and/or decrease the risk of diseases. Probiotics, ingested live beneficial bacteria, and prebiotics, the ... -
Mining milk for factors which modulate host-microbial interactions in vitro
(NUI Galway, 2021-02-03)Human milk oligosaccharides (HMO) have been reported to increase the adhesion of Bifidobacterium longum subsp. infantis ATCC 15697 (B. infantis ATCC 15697) to human colonic adenocarcinoma, HT-29 cells. In this thesis, ... -
Targeting the glycome of major milk proteins
(2016-10-20)The objectives of this thesis were to 1) explore the glycosylation of major bovine milk proteins, 2) investigate the effect of lactational stage on glycan structures and 3) examine how these documented changes may influence ... -
Towards an optimal microenvironment for nucleus pulposus regeneration: a glycobiology approach
(2013-04-11)Neck and low back pain are the two highest causes of job-related disability in the UK and the USA. These pathologies are strongly related to intervertebral disc degeneration (IVD). Disc degeneration diseases (DDD) are ...