Browsing University of Galway Theses (PhD Theses) by Title
Now showing items 1861-1880 of 2245
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The Role of the Actin Cytoskeleton in the Response of Chondrocytes to Mechanical Loading: A Computational and Experimental Investigation
(2012-09-28)The biomechanisms which govern the response of chondrocytes to mechanical stimuli are poorly understood. This thesis aims to provide a more in depth understanding of chondrocyte biomechanics by focusing on the role of actin ... -
The role of the aquatic environment in the spread of antimicrobial resistance of public health significance
(NUI Galway, 2020-02-27)Antimicrobial resistance (AMR) is one of the greatest threats to human health of the 21st Century, with certain antimicrobial resistant organisms classified as being a greater threat to public health than others. At the ... -
The role of the endocannabinoid system in neuronal alterations and behavioural responding in the valproic acid model of autism
(NUI Galway, 2020-10-20)Autism is a neurodevelopmental disorder which affects 1 in 54 children. Prenatal exposure to the antiepileptic drug valproic acid (VPA) is associated with an increased risk of autism. Similarly, prenatal exposure of rodents ... -
The role of the endocannabinoid system in the affective modulation of pain
(2015-09-30)Pain represents a major unmet clinical need and affects a large number of individuals worldwide. Numerous studies indicate a very high prevalence of chronic pain comorbid with psychiatric disorders such as anxiety and ... -
The role of the endocannabinoid system in the emotional modulation of pain
(NUI Galway, 2018-09-06)Fear-conditioned analgesia (FCA) is the robust suppression of pain that occurs upon reexposure to a context previously paired with an aversive stimulus. FCA is mediated by activation of the descending inhibitory pain ... -
The role of the endogenous opioid system in hyperalgesia associated with negative affect
(NUI Galway, 2020-02-26)Pain and negative affect (anxiety and depression) modulate one another reciprocally. However, the neurobiological mechanisms underlying this interaction are unclear. The endogenous opioid system plays a key role in regulating ... -
The role of the endogenous opioid system in social motivation and cognition in the valproic acid model of social impairment
(NUI Galway, 2019-11-11)Positive social interactions and successful relationships are important for physical and mental health, and have been shown to elicit beneficial effects on multiple physiological systems and bodily function. Impairments ... -
The Role of the European Union in Ensuring Respect for International Humanitarian Law
(2011-09-23)This research examines the role of the EU and its Member States in contributing to furthering the aims of international humanitarian law and increasing its implementation and effectiveness through its external promotion ... -
The role of the judge in the progressive development of international criminal law
(2017-01-19)International criminal law offers fertile ground for considering the role of the bench in the development of law through creative or progressive interpretative methodologies. Since its genesis at Nuremberg more than 70 ... -
The role of the liver X receptor in mitotane therapy in adrenocortical carcinoma
(NUI Galway, 2020-08-12)Adrenocortical carcinoma (ACC) is a rare, aggressive malignancy with limited treatment options. The Liver X Receptor α (LXRα) is highly expressed in the adrenal cortex, and functions to regulate cholesterol and lipid ... -
The role of the pine marten in Irish squirrel population dynamics
(2013-09-19)There are two squirrel species found in Ireland. The native red squirrel, Sciurus vulgaris, and the invasive North American grey squirrel, Sciurus carolinensis. In Ireland, the UK and Italy the grey squirrel threatens ... -
The role of tumour necrosis factor related apoptosis-inducing ligand receptor signalling in tumour immune interactions
(NUI Galway, 2023-09-18)Death receptors are members of the tumor necrosis factor receptor (TNFR) superfamily, characterised by the presence of an intracellular alpha helical fold domain, called the death domain (DD) [1][2]. There are 8 death ... -
The Role of Unconventional T Cells in the Immune Response to the Gastric Pathogen Helicobacter pylori
(2012-09-30)Helicobacter pylori (HP) is a gastric pathogen that is a known causative agent of gastritis, and peptic ulcers. It is a co-factor for the onset of gastric cancer and for these reasons is classified as a type I carcinogen. ... -
Roles of a novel serine/threonine protein kinase Ulk4 in mouse brain development and functions
(2016-05-03)SUMMARY UNC-51-like kinase 4 (ULK4) is a novel gene encoding a potential serine/threonine kinase (STK), and little is known about its functions. Limited studies have been carried out so far, and most of the current 12 ... -
The roles of centrins/caltractins at the centrosome and in genome maintenance
(2012-06-21)The principal microtubule-organising centre in animal cells, the centrosome, contains centrin, a small, highly-conserved calcium-binding protein that can be found throughout eukaryotes. Several centrin isoforms exist and ... -
Roles of DNA polymerase eta and replication protein A (RPA) in undamaged and platinum-treated human cells
(2012-09-28)Platinum-based drugs are widely used in cancer therapy. Bypass of platinum-induced DNA adducts during DNA replication by specialised DNA polymerases may contribute to drug tolerance and tumour cell resistance. Human cells ... -
The roles of microRNAs in human mesenchymal stem cell adipogenesis
(2012-05-28)The current epidemic of obesity has resulted in a renewed interest in the developmental origins of adipose tissue. Adipose tissue is formed from mesenchymal stem cells (MSCs) in a process known as adipogenesis. MicroRNAs ... -
Ruling the Borders: Wiliam Lord Dacre and the genesis of the Dacre Rising
(2011-09-29)This study examines the northern branch of the Dacre family - the Dacres of Gilsland. The west march of England towards Scotland, on the Anglo-Scottish borders, is the focal point of this thesis, as this contained the ... -
The ruling trinity transformed: negotiating power and local leadership in Ireland
(2015-09-21)This thesis examines power relations in the political, economic and religious spheres in local society in Ireland, so as to assess the contribution being made by a local leadership to a contemporary Irish social power ... -
Rural landscapes of improvement in Ireland, 1650-1850: An archaeological landscape study
(2015-01-13)Ireland's modern landscapes of fields and farms were largely fashioned in the later historic period, between c.1650 and 1850. This was the infancy of modern rural Ireland, when the concepts of property and tenure, landlords ...