An attractive, yet challenging approach to overcome poor water solubility is to convert a crystalline Active Pharmaceutical Ingredient (API) into its more soluble amorphous form.1-3 Nevertheless, the use of amorphous drug ...

The stereoselective generation of 1,2-cis linkages continues to be a substantial challenge in carbohydrate chemistry today. Lewis acid-promoted anomerisation of 1,2-trans linkages offers a facile method to generate 1,2-cis ...

1,2-cis aminoglycosides are considered difficult to prepare in a highly stereoselective manner. Some strategies have been developed to date including the preparation of 2-azido, 2-benzylidine and 2,3-oxazolidinone glycosyl ...

The use of methylmagnesium chloride (MeMgCl) as a non-nucleophilic base is explored in this thesis. Grignard reagents react in nucleophilic addition reactions with nitriles yielding a ketone upon work-up, but in the ...

Internal combustion engines that rely heavily on fuel oxidation chemical kinetics, rather than external ignition sources, promise the simultaneous improvement of thermodynamic efficiencies and reduction of pollutant emissions ...

Polymorphism control of pharmaceutical compounds is a fundamental issue in pharmaceutical companies. Solution crystallization is a well-known pharmaceutical process. There are a variety of factors that can influence the ...

Total internal reflection fluorescence microscopy (TIRFM) techniques play an important role in investigating phenomena which occur on transparent dielectric surfaces at nanometre scales in various research fields from ...

Protein aggregation is one of the biggest challenges affecting the manufacture and safe use of biopharmaceuticals. Despite efforts made to enhance protein stability [1], aggregation still remains a critical factor in ...

Alkyl 2-cyanoacrylates (CAs) are primarily used as instant adhesives, including those sold under the Loctite brand. The adhesive action can be inhibited with acid stabilisers allowing radical polymerization to be employed. ...

Chapter 1 The traditional thermal Mannich reaction is unsuitable for preparing polymerizable N-methylene amino substituted acrylamides and methacrylamides. Herein we provide a facile multi-gram high yield synthesis of these ...