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The Reversible Addition-Fragmentation Chain Transfer (RAFT) polymerization of cyanoacrylates
(2018-02-02)
Alkyl 2-cyanoacrylates (CAs) are primarily used as instant adhesives, including those sold under the Loctite brand.
The adhesive action can be inhibited with acid stabilisers allowing radical polymerization to be employed. ...
Amorphous pharmaceuticals and composites
(NUI Galway, 2018-04-27)
An attractive, yet challenging approach to overcome poor water solubility is to convert a crystalline Active Pharmaceutical Ingredient (API) into its more soluble amorphous form.1-3 Nevertheless, the use of amorphous drug ...
The combustion of fuel reference compounds in laboratory-scale reactors and flames
(NUI Galway, 2018-05-14)
Internal combustion engines that rely heavily on fuel oxidation chemical kinetics, rather than external ignition sources, promise the simultaneous improvement of thermodynamic efficiencies and reduction of pollutant emissions ...
The investigation of methylmagnesium chloride as a non-nucleophilic base
(NUI Galway, 2018-11-30)
The use of methylmagnesium chloride (MeMgCl) as a non-nucleophilic base is explored in this thesis.
Grignard reagents react in nucleophilic addition reactions with nitriles yielding a ketone upon work-up, but in the ...
Anisotropy resolved multidimensional emission spectroscopy (ARMES) for the analysis and resolution of insulin oligomer emission
(NUI Galway, 2018-11-14)
Protein aggregation is one of the biggest challenges affecting the manufacture and safe use of biopharmaceuticals. Despite efforts made to enhance protein stability [1], aggregation still remains a critical factor in ...
Green solvent free methods for active pharmaceutical ingredient polymorph control
(NUI Galway, 2018-09-28)
Polymorphism control of pharmaceutical compounds is a fundamental issue in pharmaceutical companies. Solution crystallization is a well-known pharmaceutical process. There are a variety of factors that can influence the ...
Reversible addition fragmentation chain transfer (RAFT) of a new class of pH-sensitive monomers and polymerization induced self-assembly (PISA) in supercritical carbon dioxide
(NUI Galway, 2018-10-15)
Chapter 1 The traditional thermal Mannich reaction is unsuitable for preparing polymerizable N-methylene amino substituted acrylamides and methacrylamides. Herein we provide a facile multi-gram high yield synthesis of these ...
Using Total Internal Reflection Fluorescence Microscopy (TIRFM) for studying protein-surface interactions
(NUI Galway, 2018-09-10)
Total internal reflection fluorescence microscopy (TIRFM) techniques play an important role in investigating phenomena which occur on transparent dielectric surfaces at nanometre scales in various research fields from ...
Studies in anomerisation of glycosyl thiols and glycosides
(NUI Galway, 2018-06-29)
The stereoselective generation of 1,2-cis linkages continues to be a substantial challenge in
carbohydrate chemistry today. Lewis acid-promoted anomerisation of 1,2-trans linkages offers
a facile method to generate 1,2-cis ...
A study in carbohydrate chemistry: From anomerisation to synthesis of glycoclusters based on neoglycopeptides
(NUI Galway, 2018-08-08)
1,2-cis aminoglycosides are considered difficult to prepare in a highly stereoselective manner. Some strategies have been developed to date including the preparation of 2-azido, 2-benzylidine and 2,3-oxazolidinone glycosyl ...