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Centrobin functions in centriole duplication, primary ciliogenesis and genome maintenance
(2018-03-06)
The centrosome is composed of numerous proteins that make up its core structure. Other proteins also transiently localise and interact with centrosomal proteins for functional modulation. Centrobin, one of the core centrosomal ...
Information systems project portfolio management as a complex adaptive system: The CAPPP framework
(2018-01-29)
Project portfolio management (PPM) has been subject to very little investigation in information systems (IS) research. This is surprising, given the huge global expenditure on IS, the high levels of failure at the project ...
Characterization of PIWI+ stem cells in Hydractinia
(2018-02-23)
Hydractinia is a colonial marine invertebrate and a member of the phylum Cnidaria. It represents a very powerful tool for studying basic developmental biology and differentiation due to the presence of a population of stem ...
An evaluation of the SPARX-R computerised mental health programme for improving mental health and wellbeing among adolescents attending alternative education
(2018-02-22)
Introduction
International evidence suggests that youth who leave mainstream education early have poorer mental health and social outcomes than their peers. In the European Union, 11.1% of youth leave mainstream education ...
Factors that influence good end of life care in long stay residential care for older people
(2018-02-21)
Aim: To generate a grounded theory to understand the factors that influence end of life care in long stay residential care homes. Background: In this study, the term of ‘end-of-life’ is described as a continuum, rather ...
Investigating the impact of genomic profiling on breast cancer risk prediction, treatment and outcome
(2018-02-05)
It has, for many years, been acknowledged that “breast cancer” is an umbrella term for many genetically and immunophenotypically distinct malignancies of the breast. Treatment paradigms are shifting in direct response to ...
Novel functions for the CENP-A N-terminus during male meiosis in Drosophila melanogaster
(NUI Galway, 2018-03-23)
Recent studies in plants and Drosophila suggest that CENP-A, the centromeric histone H3 variant and epigenetic marker of centromere localisation may have additional roles during meiosis. By immunoprecipitation and mass ...
Trends in the incidence and outcomes of end stage kidney disease from specific causes and the ability of measures of kidney function to predict mortality in community dwelling individuals
(NUI Galway, 2018-03-09)
Summary of Contents
There are two broad themes in this research thesis. The first is an exploration of the ability of measures of kidney function and urinary protein excretion to predict death based on non-parametric ...
"Extraordinary Debilities": Disability in the works of Samuel Beckett, 1928-45
(2018-02-16)
This thesis considers the importance of Samuel Beckett’s representations of disability in the first half of the twentieth-century. It suggests that the innovations of form that Beckett brings to modernism are inextricably ...
Waves, wrinkles and creases in deformed soft solids
(NUI Galway, 2018-07-10)
This article-based thesis comprises a collection of four articles, each of which constitutes a chapter written and formatted in pre-print manuscript form. The general aim underlying these articles is to model the large ...