Search
Now showing items 11-15 of 15
Study of silyl protecting groups in anomerisation reactions: Total synthesis of a glycolipid from Plakortis simplex and its mimetics
(NUI Galway, 2019-02-04)
This thesis deals with anomerisation, which is, in other words, epimerisation at the anomeric centre, usually interpreted as being from the equatorial to the axial anomer. An objective was to enhance the knowledge of this ...
Carbohydrates in the synthesis of macrocycles and glycoclusters
(NUI Galway, 2019-01-28)
This thesis deals with efforts to generate new bioactive organic compounds. The main focus
has been on the use of carbohydrate building blocks for synthesis of both macrocyclic
compounds and glycoclusters for biological ...
Investigation of various ligand design approaches and synthesis of diverse heterocyclic bioactive compounds
(NUI Galway, 2019-09-27)
Structure-based design and ligand-based design are one of the most common approaches used to develop new inhibitors against druggable protein targets in various human disorders. Mcl-1 is a protein belongs to Bcl-2 family ...
Synthesis and evaluation of multivalent ligands for macrophage galactose C-type lectin. Development of new chemical tools for immunological research and structural investigation of the lectin with GalNAc and derivatives
(NUI Galway, 2019-09-30)
Synthetic chemistry can provide powerful tools to explore the correlation between an antigen’s
chemical structure and the type of immune response triggered. This thesis work has focused
on the design, synthesis and ...
Small-molecule-based crosslinking and bioconjugation of biomolecules
(NUI Galway, 2020-01-10)
Chapter 1: The chemical modification and bioconjugation of proteins is an expanding yet challenging area of chemical biology. The superior nucleophilicity of cysteine presents it as a uniquely reactive bioconjugation handle. ...