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Now showing items 11-20 of 25
The potential of injectable collagen hydrogels to enhance dopaminergic cell replacement therapies for Parkinson's disease
(NUI Galway, 2018-10-04)
Extensive pre-clinical and clinical assessment has shown that, when transplanted into the Parkinsonian brain, primary dopaminergic neurons can survive, integrate with the host system, produce dopamine and provide functional ...
Evaluation of the efficacy of the Baska Mask
(NUI Galway, 2018-03-22)
The Baska mask is a new supraglottic airway device (SAD). Its novel features include a non-inflatable cuff consisting of a silicone membrane, and an oesophageal drainage system with sump reservoir, connected to 2 drainage ...
Characterisation of sex differences in behavioural domains and antidepressant response in two rat models of depression
(NUI Galway, 2018-10-17)
Although the rate of depression is known to be almost twice as high in women compared to men, most evaluation of antidepressant efficacy involved only males until the early 1990s. In pre-clinical depression research male ...
Stem cell modelling for the role of NRXN1 deletion in Autism Spectrum Disorder
(NUI Galway, 2018-12-21)
Autism spectrum disorder (ASD), a multi-factorial disease, often has co-morbidity with epilepsy, which is associated with excessive neuronal firing. The pre-synaptic protein Neurexin1 (NRXN1) signals bi-directionally through ...
Statistical and geographic analysis of out-of-hospital cardiac arrest using registry data
(NUI Galway, 2018-10-08)
Background: Out-of-hospital cardiac arrest (OHCA) is the most critical health event that occurs in the community. When the heart stops pumping blood, if resuscitation is not started, biological death will occur within ...
Immunomodulation in mesenchymal stem cell therapy for osteoarthritis: mechanistic insights on the role of cell death and engraftment
(NUI Galway, 2018-11-02)
Osteoarthritis (OA) is a degenerative pathology of the articular cartilage causing chronic
pain and disability in millions of individuals. In OA synovia, resident macrophages and
infiltrated lymphocytes contribute to the ...
Metastatic breast cancer: Patterns of metastasis and novel biomarkers
(NUI Galway, 2018-05-25)
Breast cancer is a heterogeneous disease and is the leading cause of cancer-related deaths among women, with metastatic disease the principle cause of mortality. In recent years great advances have been made in stratifying ...
Optimisation and characterisation of cholecyst-derived extracellular matrix for abdominal wall reconstruction
(NUI Galway, 2018-10-19)
Polypropylene mesh was created by Usher in 1962 after he experienced unsatisfactory
results from using autografts and allografts for hernia repairs. More than fifty years later,
polypropylene is still the most popular ...
Ex Vivo slice culture model of rat spinal cord injury as a platform for testing proposed treatment strategies
(NUI Galway, 2018-04-13)
There are several detrimental events that occur in the aftermath of a spinal cord injury (SCI); these include glial scar formation, accumulation of axon growth inhibitors and immune mediators. These events present challenges ...
Mastectomy and breast reconstruction in the modern era: the role of neoadjuvant therapies and regenerative surgery
(NUI Galway, 2018-10-09)
Complete surgical resection with disease free margins remains the cornerstone of effective breast cancer treatment. Breast cancer management continues to evolve with the development of more sophisticated techniques of ...