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Now showing items 1-10 of 11
Smart biomaterials for cell sheet engineering
(2016-03-23)
The aim of this instigation was to develop thermoresponsive polymer films for cell culture use. Conventional cell detachment methods involve the use of proteolytic enzymes, such as trypsin, or mechanical scrapping. These ...
The benign synthesis of bioactive heterocycles using photochemistry and hydrogen peroxide with hydrohalic acids
(2016-07-08)
Chapter 1 provides a pertinent review of recent photochemical homolytic aromatic substitution (HAS) literature. Photochemical methods for HAS include UV-light and visible light photoredox catalysis. Recently invented methods ...
Protein interactions in physiological environments
(2016-06-03)
The interactions of three proteins (ΔTat-GB1, cytochrome c and flavodoxin) were explored in Escherichia coli cells and extracts. The results indicate features of the physicochemical basis for protein assembly in the complex ...
Exploring a novel class of fluorophores: the 2,5-dihydro-1,2,3-triazines
(2016-09-27)
The 1,2,3-triazines, also known as the v-triazines, are the least studied of the three classes of triazine. This is due to the ring’s lower stability and more limited synthetic routes. A new class of fluorophores, based ...
Surface modification of electrodes for enzymatic fuel cell application
(2016-01-07)
The immobilisation chemistry of enzymes and redox complexes capable of shuttling electrons between enzymes and electrode surface can have an impact on the magnitude and stability of current response, with implications for ...
Anisotropy resolved multi-dimensional emission spectroscopy (ARMES): a new tool for the quantitative and structural analysis of proteins
(NUI Galway, 2016-03-24)
The quantitative and structural analysis of proteins is of great importance in numerous fields (from industrial to academic research). Requirements like ease of analysis, sample handling, robustness, analysis time, the ...
Design and synthesis of macrocycles, peptides and coiled coils with sugar connections
(2016-06-09)
Migrastatin is a secondary metabolite that is formed from the bacterium Streptomyces platensis. This compound has shown promising anti-metastatic activity by inhibiting tumour cell migration. Published derivatives of this ...
A study of factors influencing anomerisation reactions
(2016-07-18)
This thesis involves an investigation into the anomerisation reaction and strategies by which the reaction can potentially be improved and provide a greater understanding of factors influencing the reaction. There has been ...
Development of glucose-oxidising enzyme electrodes for application in glucose|oxygen powered enzymatic fuel cells
(2016-02)
The objective of this thesis is to investigate different strategies for the optimisation
of biocatalytic anodes with a view to developing a semi- or fully implantable,
miniature, membrane-less enzymatic fuel cell via ...
On the oxidation of alkanes and thermodynamic properties of nitrogen-containing compounds: experimental, theoretical, and kinetic modelling studies
(2016-09-21)
The primary focus of the work presented in this Thesis involved a major re-evaluation of detailed chemical kinetic models describing alkane oxidation under combustion conditions. Combined experimental and theoretical ...