Browsing University of Galway Theses by Title
Now showing items 1539-1558 of 2276
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Nonlinear analysis for ranking and evaluating the singular and collective impacts of project delay factors in Saudi Arabia
(NUI Galway, 2019-04-30)One of the biggest engineering concerns in the Middle East is the major delays in infrastructural projects which impact on both their quality and cost. A significant number of projects do not finish on time, are subject ... -
Novel approaches to the understanding and treatment of postoperative pain
(NUI Galway, 2019-12-06)Postoperative pain constitutes a significant medical need. Greater understanding of the mechanisms will allow for more effective treatments. The endogenous cannabinoid (endocannabinoid) and opioid systems play a key role ... -
Novel Cell-Based Therapies for the Treatment of Diabetic Ulceration
(2012-02-28)The focus of this research is on developing novel cell based therapies for the treatment of non-healing diabetic foot ulceration. The thesis begins with a concise review of the diabetic foot ulcers. The burden associated ... -
Novel computational biomechanics for the assessment of coronary plaque vulnerability and its clinical implications
(NUI Galway, 2023-06-12)Acute coronary syndromes (ACS) continue to be one of the major causes of mortality around the world. Accumulating evidence indicates that thrombosis plays a critical role in the pathogenesis of ACS. Autopsy studies have ... -
Novel computational functional assessment of coronary stenosis and its clinical applications in predicting and evaluating procedural results
(NUI Galway, 2023-06-13)Coronary angiography has limited efficacy in identifying patients with suboptimal results after percutaneous coronary intervention (PCI). Immediate post-procedural functional assessment, including fractional flow reserve ... -
Novel functions for the CENP-A N-terminus during male meiosis in Drosophila melanogaster
(NUI Galway, 2018-03-23)Recent studies in plants and Drosophila suggest that CENP-A, the centromeric histone H3 variant and epigenetic marker of centromere localisation may have additional roles during meiosis. By immunoprecipitation and mass ... -
Novel gene therapeutic approaches to prolong corneal allograft survival
(2012-09-28)Cornea transplantation (penetrating keratoplasty) is the most frequent form of allograft transplantation in humans with a 90 % success rate in the first 2 years, however, the rate of survival decreases over time and drops ... -
Novel high-resolution imaging modalities for monitoring in vitro models of cartilage degeneration and mesenchymal stem cell therapy in osteoarthritis
(NUI Galway, 2023-06-20)Osteoarthritis (OA) is a chronic disease of synovial joints characterized by progressive degeneration of articular cartilage causing pain and disability in millions of people worldwide. Current imaging systems used for ... -
Novel insights into allele-specific expression and translation in human lymphoblastoid cell lines through integrative analysis of transcriptomic and ribosome profiling data
(NUI Galway, 2018-08-20)The rate of mRNA translation makes an important contribution to determining protein abundance in cells and genetic variants that affect the rate at which a protein is synthesized may give rise to human genetic diseases and ... -
Novel Insights into Chromatin Structure and Gene Regulation through Integrative Analysis of High Throughput Genomics Data
(2014-01-14)Genetics and epigenetics research has evolved dramatically over the last decade, owing to rapid developments in high-throughput genomics techniques. Analysis of the resulting quantities of data requires advanced computational ... -
Novel insights into the molecular roles of UBP5 in controlling chromatin dynamics and plant development
(NUI Galway, 2023-04-03)Polycomb group (PcG) proteins are conserved chromatin regulators essential for controlling key developmental programs in eukaryotes. PcG proteins assemble together to form multi-protein complexes known as Polycomb ... -
Novel mechanisms for neoadjuvant chemotherapeutic response monitoring in breast cancer
(2016-11-25)Breast cancer is the most frequently diagnosed female malignancy worldwide, causing the majority of cancer-related deaths amongst women. While the management of this disease has transformed dramatically in recent years, ... -
Novel mechanobiological modelling of bone metastasis reveals that substrate stiffness, biochemical bone cell signaling and mechanical stimulation alter metastatic activity
(NUI Galway, 2023-03-01)For more than 70% of breast cancer patients, cancer cells spread from their primary site and metastasize to bone. Although much research has been conducted to understand the pathogenesis of the metastatic bone disease, ... -
Novel methods for the planning and design of greenways for cycling
(2016-05-12)There is a crisis in transport internationally as the continuing proliferation of car-use undermines environment, society and economy. Cycling has gained considerable attention in policy and academia in recent years as one ... -
Novel methods of benthic habitat assessment in designated waterbodies around Ireland
(2017-01-06)The European Union has implemented some of the most progressive conservation Directives in the world. These Directives are implemented in different ways, have different reporting cycles and use unique terminologies. The ... -
Novel multiplex isothermal nucleic acid amplification technologies for the detection of bacterial meningitis associated pathogens
(NUI Galway, 2019-02-28)Infectious diseases, caused by pathogenic microorganisms such as bacteria, fungi or viruses, are a leading cause of significant global morbidity and mortality, with over 10 million associated deaths reported each year. ... -
Novel strategies for exploitation of milk glycoproteins for food ingredient applications
(NUI Galway, 2019-08-02)This thesis sets out to explore the potential bioactivities associated with the bovine milk proteome with a view to improving our understanding of the roles bovine milk proteins may play in human health promotion. The ... -
Nuachainteoirí agus Euskaldunberriak: Mudes, idé-eolaíochtaí teanga agus féiniúlachtaí
(NUI Galway, 2020-02-28)Staidéar sochtheangeolaíoch criticiúil atá sa tráchtas seo, ina mbreathnaím ar mudes teangeolaíocha, idé-eolaíochtaí teanga agus féiniúlachtaí nuachainteoirí óga na Gaeilge. Bainim leas as comhthéacs na Bascaise, agus ... -
Nucleolar DNA damage within the female gametophyte perturbs development and genome stability in Arabidopsis thaliana
(NUI Galway, 2021-12-10)The 45S rRNA genes (rDNA) are among the largest repetitive elements in eukaryotic genomes. rDNA consists of tandem arrays of rRNA genes, many of which are transcriptionally silenced. Silent rDNA repeats may act as ‘back-up’ ... -
Nucleolar reorganisation promotes repair of rDNA double strand breaks by homologous recombination throughout the cell cycle.
(2013-12-16)The nucleolus is the largest functional domain within the nucleus and is the site of ribosome biogenesis. It has a distinct structure and houses ribosomal RNA gene (rDNA) transcription, pre-ribosomal RNA (pre-rRNA) processing, ...