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Engineering recombinant antibodies for polymer biofunctionalization
(Wiley, 2015-08-18)
The attachment of recognition elements such as antibody fragments to polymeric substrates can be used to mediate cell- or protein-specific interactions. In this work, single-chain Fv (scFv) antibody fragments were isolated ...
Systems-based approaches to unravel multi-species microbial community functioning
(Research Network of Computational and Structural Biotechnology, 2014-12-03)
Some of the most transformative discoveries promising to enable the resolution of this century's grand societal
challenges will most likely arise from environmental science and particularly environmental microbiology ...
Comparative genome analysis identifies novel nucleic acid diagnostic targets for use in the specific detection of Haemophilus influenzae
(Elsevier, 2015-06-23)
Haemophilus influenzae is recognised as an important human pathogen associated with invasive infections, including bloodstream infection and meningitis. Currently used molecular-based diagnostic assays lack specificity in ...
Nerve growth factor-mediated inhibition of apoptosis post-caspase activation is due to removal of active caspase-3 in a lysosome-dependent manner
(Nature Publishing Group, 2014-05-01)
Nerve growth factor (NGF) is well characterised as an important pro-survival factor in neuronal cells that can inhibit apoptotic cell death upstream of mitochondrial outer membrane permeabilisation. Here we addressed the ...
Variability of candidate genes, genetic structure and association with sugar accumulation and climacteric behavior in a broad germplasm collection of melon (Cucumis melo L.)
(BioMed Central, 2015-03-19)
Background: A collection of 175 melon (Cucumis melo L.) accessions (including wild relatives, feral types, landraces, breeding lines and commercial cultivars) from 50 countries was selected to study the phenotypic variability ...
Neurotrophins and B-cell malignancies
(Springer Verlag, 2015-09-23)
Neurotrophins and their receptors act as important proliferative and pro-survival factors in a variety of cell types. Neurotrophins are produced by multiple cell types in both pro and mature forms, and can act in an autocrine ...
Stress management at the ER: regulators of ER stress-induced apoptosis.
(Elsevier, 2012-02-17)
The endoplasmic reticulum (ER) is an elaborate cellular organelle essential for cell function and survival. Conditions that interfere with ER function lead to the accumulation and aggregation of unfolded proteins which are ...
A rapid culture independent methodology to quantitatively detect and identify common human bacterial pathogens associated with contaminated high purity water
(BioMed Central, 2015-02-18)
Water and High Purity Water (HPW) distribution systems can be contaminated with human
pathogenic microorganisms. This biocontamination may pose a risk to human health as HPW is commonly used in
the industrial, pharmaceutical ...
Comparison of established diagnostic methodologies and a novel bacterial smpB real-time PCR assay for the specific detection of haemophilus influenzae associated with respiratory tract infections
(American Society for Microbiology, 2015-06-23)
Haemophilus influenzae is a significant causative agent of respiratory tract infections (RTI) worldwide. The development of a
rapid H. influenzae diagnostic assay that would allow for the implementation of infection control ...
Low-temperature anaerobic digestion is associated with differential methanogenic protein expression
(Oxford University Press, 2015-04-09)
Anaerobic digestion (AD) is an attractive wastewater treatment technology, leading to the generation of recoverable biofuel (methane). Most industrial AD applications, carry excessive heating costs, however, as AD reactors ...