Now showing items 1-4 of 4

    • Effects of nerve bundle geometry on neurotrauma evaluation 

      Cinelli, Ilaria; Destrade, Michel; McHugh, Peter; Duffy, Maeve (Wiley, 2018-06-16)
      ObjectiveWe confirm that alteration of a neuron structure can induce abnormalities in signal propagation for nervous systems, as observed in brain damage. Here, we investigate the effects of geometrical changes and damage ...
    • Electro-mechanical response of a 3D nerve bundle model to mechanical loads leading to axonal injury 

      Cinelli, Ilaria; Destrade, Michel; Duffy, Maeve; McHugh, Peter (Wiley, 2017-11-21)
      Traumatic brain injuries and damage are major causes of death and disability. We propose a 3D fully coupled electro-mechanical model of a nerve bundle to investigate the electrophysiological impairments due to trauma at ...
    • Label free ultra-sensitive imaging with sub-diffraction spatial resolution 

      Alexandrov, Sergey; Das, Nandan; McGrath, James; Owens, Peter; Sheppard, Colin J. R.; Boccafoschi, Francesca; Giannini, Cinzia; Sibillano, Teresa; Subhash, Hrebesh; Leahy, Martin (IEEE, 2019-07-09)
      In this paper, we show a new way to break the resolution limit and dramatically improve sensitivity to structural changes. To realize it we developed a novel label free contrast mechanism, based on the spectral encoding ...
    • Spatial frequency domain correlation mapping optical coherence tomography for nanoscale structural characterization 

      Alexandrov, Sergey; McNamara, Paul M.; Das, Nandan; Zhou, Yi; Lynch, Gillian; Hogan, Josh; Leahy, Martin (AIP Publishing, 2019-09-16)
      Most of the fundamental pathological processes in living tissues exhibit changes at the nanoscale. Noninvasive, label-free detection of structural changes in biological samples pose a significant challenge to both researchers ...