Browsing School of Chemistry (Scholarly Articles) by Author "Saudi Arabia Government Scholarship"
Now showing items 1-3 of 3
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Dual-drug amorphous formulation of gliclazide
Aljohani, Marwah; McArdle, Patrick; Erxleben, Andrea (Taylor and Francis, 2021-02-01)Amorphization is a well-established strategy to enhance the dissolution properties of poorly water-soluble drugs. However, the amorphous state is inherently unstable toward recrystallization. Coamorphous systems of a drug ... -
Investigation of the formation of drug-drug cocrystals and coamorphous systems of the antidiabetic drug gliclazide
Aljohani, Marwah; MacFhionnghaile, Pól; McArdle, Patrick; Erxleben, Andrea (Elsevier, 2019-02-23)The antidiabetic drug gliclazide (GLZ) has a slow absorption rate and a low bioavailability due to its poor solubility. GLZ is often prescribed along with an antihypertensive, as many diabetic patients have coexistent ... -
The very different effect of water on nucleation, crystallization, and hydrate stability of zingerone and vanillate esters
Aljohani, Marwah; McArdle, Patrick; Erxleben, Andrea (American Chemical Society, 2020-01-09)Vanillin and vanillate esters are widely used as flavorings in the food industry, and the vanillin derivative zingerone is one of the compounds found in the spice ginger. Neither the growth of single crystals of zingerone ...