Browsing by Author "Duffy, Garry P."
Now showing items 1-13 of 13
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A collagen cardiac patch incorporating alginate microparticles permits the controlled release of hepatocyte growth factor and insulin-like growth factor-1 to enhance cardiac stem cell migration and proliferation
O'Neill, Hugh S.; O'Sullivan, Janice; Porteous, Niamh; Ruiz-Hernandez, Eduardo; Kelly, Helena M.; O'Brien, Fergal J.; Duffy, Garry P. (Wiley-Blackwell, 2017-06-19) -
Advanced Material Catheter (AMCath), a minimally invasive endocardial catheter for the delivery of fast-gelling covalently cross-linked hyaluronic acid hydrogels
Dolan, Eimear B.; Kovarova, Lenka; O'Neill, Hugh; Pravda, Martin; Sulakova, Romana; Scigalkova, Ivana; Velebny, Vladimir; Daro, Dorothee; Braun, Nathalie; Cooney, Gerard M .; Bellavia, Gabriella; Straino, Stefania; Cavanagh, Brenton L.; Flanagan, Aiden; Kelly, Helena M.; Kelly, Helena M.; Duffy, Garry P.; Murphy, Bruce P. (SAGE Publications, 2018-10-25)Injectable hydrogels that aim to mechanically stabilise the weakened left ventricle wall to restore cardiac function or to deliver stem cells in cardiac regenerative therapy have shown promising data. However, the clinical ... -
Advanced therapies in pancreatic islet transplantation for type 1 diabetes mellitus
Wallace, Eimear J. (NUI Galway, 2023-03-14)Type 1 diabetes mellitus is an autoimmune condition whereby β-cells are destroyed by the immune system causing the lack/absence of insulin production and resultant hyperglycaemia. Pancreatic islet transplantation is ... -
Biomaterial-enhanced cell and drug delivery: lessons learned in the cardiac field and future perspectives
O'Neill, Hugh S.; Gallagher, Laura B.; O'Sullivan, Janice; Whyte, William; Curley, Clive; Dolan, Eimear; Hameed, Aamir; O'Dwyer, Joanne; Payne, Christina; O'Reilly, Daniel; Ruiz-Hernandez, Eduardo; Roche, Ellen T.; O'Brien, Fergal J; Cryan, Sally Ann; Kelly, Helena; Murphy, Bruce; Duffy, Garry P. (Wiley-Blackwell, 2016-02-03)Heart failure is a significant clinical issue. It is the cause of enormous healthcare costs worldwide and results in significant morbidity and mortality. Cardiac regenerative therapy has progressed considerably from clinical ... -
A bioresorbable biomaterial carrier and passive stabilization device to improve heart function post-myocardial infarction
Dolan, Eimear B.; Hofmann, Björn; de Vaal, M. Hamman; Bellavia, Gabriella; Straino, Stefania; Kovarova, Lenka; Pravda, Martin; Velebny, Vladimir; Daro, Dorothee; Braun, Nathalie; Monahan, David S.; Levey, Ruth E.; O'Neill, Hugh; Hinderer, Svenja; Greensmith, Robert; Monaghan, Michael G.; Schenke-Layland, Katja; Dockery, Peter; Murphy, Bruce P.; Kelly, Helena M.; Wildhirt, Stephen; Duffy, Garry P. (Elsevier, 2019-05-15)The limited regenerative capacity of the heart after a myocardial infarct results in remodeling processes that can progress to congestive heart failure (CHF). Several strategies including mechanical stabilization of the ... -
Development of a thermoresponsive chitosan gel combined with human mesenchymal stem cells and desferrioxamine as a multimodal pro-angiogenic therapeutic for the treatment of critical limb ischaemia
Hastings, Conn L.; Kelly, Helena M.; Murphy, Mary J.; Barry, Frank P.; O'Brien, Fergal J.; Duffy, Garry P. (Elsevier BV, 2012-07-01) -
Direct uv-triggered thiol–ene cross-linking of electrospun polyester fibers from unsaturated poly(macrolactone)s and their drug loading by solvent swelling
de Oliveira, Fernando C. S.; Olvera, Dinorath; Sawkins, Michael J.; Cryan, Sally-Ann; Kimmins, Scott D.; da Silva, Tatiane Eufrasio; Kelly, Daniel J.; Duffy, Garry P.; Kearney, Cathal; Heise, Andreas (American Chemical Society (ACS), 2017-11-14)Electrospinning is considered a relatively simple and versatile technique to form high porosity porous scaffolds with micron to nanoscale fibers for biomedical applications. Here, electrospinning of unsaturated aliphatic ... -
Dynamic actuation enhances transport and extends therapeutic lifespan in an implantable drug delivery platform
Whyte, William; Goswami, Debkalpa; Wang, Sophie X.; Fan, Yiling; Ward, Niamh A.; Levey, Ruth E.; Beatty, Rachel; Robinson, Scott T.; Sheppard, Declan; O’Connor, Raymond; Monahan, David S.; Trask, Lesley; Mendez, Keegan L.; Varela, Claudia E.; Horvath, Markus A.; Wylie, Robert; O’Dwyer, Joanne; Domingo-Lopez, Daniel A.; Rothman, Arielle S.; Duffy, Garry P.; Dolan, Eimear B.; Roche, Ellen T. (Nature Research, 2022-08-03)Fibrous capsule (FC) formation, secondary to the foreign body response (FBR), impedes molecular transport and is detrimental to the long-term efficacy of implantable drug delivery devices, especially when tunable, temporal ... -
High levels of ephrinb2 over-expression increases the osteogenic differentiation of human mesenchymal stem cells and promotes enhanced cell mediated mineralisation in a polyethyleneimine-ephrinb2 gene-activated matrix
Tierney, Erica G.; McSorley, Kevin; Hastings, Conn L.; Cryan, Sally-Ann; O'Brien, Timothy; Murphy, Mary J.; Barry, Frank P.; O'Brien, Fergal J.; Duffy, Garry P. (Elsevier BV, 2013-02-01) -
An injectable alginate/extra cellular matrix (ECM) hydrogel towards acellular treatment of heart failure
Curley, Clive J.; Dolan, Eimear B.; Otten, Matthias; Hinderer, Svenja; Duffy, Garry P.; Murphy, Bruce P. (Springer Verlag, 2018-12-03)As treatments for myocardial infarction (MI) continue to improve, the population of people suffering from heart failure (HF) is rising significantly. Novel treatment strategies aimed at achieving long-term functional ... -
Olfactory derived stem cells delivered in a biphasic conduit promote peripheral nerve repair in vivo
Roche, Phoebe; Alekseeva, Tijna; Widaa, Amro; Ryan, Alan; Matsiko, Amos; Walsh, Michael; Duffy, Garry P.; O'Brien, Fergal J. (Wiley-Blackwell, 2017-09-28)Peripheral nerve injury presents significant therapeutic challenges for recovery of motor and sensory function in patients. Different clinical approaches exist but to date there has been no consensus on the most effective ... -
Pre-culture of mesenchymal stem cells within RGD-modified hyaluronic acid hydrogel improves their resilience to ischaemic conditions
Gallagher, Laura B.; Dolan, Eimear B.; O'Sullivan, Janice; Levey, Ruth; Cavanagh, Brenton L.; Kovarova, Lenka; Pravda, Martin; Velebny, Vladimir; Farrell, Tom; O'Brien, Fergal J.; Duffy, Garry P. (Elsevier, 2020-03-04)The incorporation of the RGD peptide (arginine-glycine-aspartate) into biomaterials has been proposed to promote cell adhesion to the matrix, which can influence and control cell behaviour and function. While many studies ... -
Towards an additive manufactured macroencapsulation device for islet cell replacement therapy
Levey, Ruth E. (NUI Galway, 2020-07-28)Islet encapsulation devices can induce a Foreign Body Response (FBR) and the formation of a hardened avascular fibrotic capsule. This FBR is heightened when the device features a smooth surface as fibrous tissue is unable ...