Biomaterial-enhanced cell and drug delivery: lessons learned in the cardiac field and future perspectives
View/ Open
Full Text
Date
2016-02-03Author
O'Neill, Hugh S.
Gallagher, Laura B.
O'Sullivan, Janice
Whyte, William
Curley, Clive
Dolan, Eimear
Hameed, Aamir
O'Dwyer, Joanne
Payne, Christina
O'Reilly, Daniel
Ruiz-Hernandez, Eduardo
Roche, Ellen T.
O'Brien, Fergal J
Cryan, Sally Ann
Kelly, Helena
Murphy, Bruce
Duffy, Garry P.
Metadata
Show full item recordUsage
This item's downloads: 0 (view details)
Cited 44 times in Scopus (view citations)
Recommended Citation
O'Neill, Hugh S. Gallagher, Laura B.; O'Sullivan, Janice; Whyte, William; Curley, Clive; Dolan, Eimear; Hameed, Aamir; O'Dwyer, Joanne; Payne, Christina; O'Reilly, Daniel; Ruiz-Hernandez, Eduardo; Roche, Ellen T.; O'Brien, Fergal J; Cryan, Sally Ann; Kelly, Helena; Murphy, Bruce; Duffy, Garry P. (2016). Biomaterial-enhanced cell and drug delivery: lessons learned in the cardiac field and future perspectives. Advanced Materials 28 (27), 5648-5661
Published Version
Abstract
Heart failure is a significant clinical issue. It is the cause of enormous healthcare costs worldwide and results in significant morbidity and mortality. Cardiac regenerative therapy has progressed considerably from clinical and preclinical studies delivering simple suspensions of cells, macromolecule, and small molecules to more advanced delivery methods utilizing biomaterial scaffolds as depots for localized targeted delivery to the damaged and ischemic myocardium. Here, regenerative strategies for cardiac tissue engineering with a focus on advanced delivery strategies and the use of multimodal therapeutic strategies are reviewed.