Browsing by Title
Now showing items 8871-8890 of 14472
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N- and O- linked Glycosylation, Developing Mass Spectrometric Strategies for the Characterisation of Glyco-epitopes
(2012-12-10)The overall goal of this thesis was to adopt a liquid chromatography-mass spectrometry (LC-MS) platform for glycomic analysis of glycoproteins. In particular we were interested in characterizing complex glycomic samples ... -
N-acetylcysteine protects striated muscle in a model of compartment syndrome
(Springer Nature, 2010-03-23)Background To avoid ischemic necrosis, compartment syndrome is a surgical emergency treated with decompression once identified. A potentially lethal, oxidant-driven reperfusion injury occurs after decompression. N-acetylcysteine ... -
N-Alkyl-1,5-dideoxy-1,5-imino-l-fucitols as fucosidase inhibitors: Synthesis, molecular modelling and activity against cancer cell lines
(Elsevier, 2018-12-04)1,5-Dideoxy-1,5-imino-l-fucitol (1-deoxyfuconojirimycin, DFJ) is an iminosugar that inhibits fucosidases. Herein, N-alkyl DFJs have been synthesised and tested against the ¿-fucosidases of T. maritima (bacterial origin) ... -
N-glycosylation of mouse trail-r and human trail-r1 enhances trail-induced death
(Springer Nature, 2017-02-10)APO2L/TRAIL (TNF-related apoptosis-inducing ligand) induces death of tumor cells through two agonist receptors, TRAIL-R1 and TRAIL-R2. We demonstrate here that N-linked glycosylation (N-glyc) plays also an important ... -
N-palmitoylethanolamide in the anterior cingulate cortex attenuates inflammatory pain behaviour indirectly via a CB1 receptor-mediated mechanism
(Lippincott, Williams & Wilkins, 2016-12)The neural substrates and mechanisms mediating the antinociceptive effects of the endogenous bioactive lipid, N-palmitoylethanolamide (PEA), require further investigation. We investigated the effects of exogenous PEA ... -
N-wasp is a novel regulator of hair-follicle cycling that controls antiproliferative tgf pathways
(The Company of Biologists, 2009-12-16)N-WASP is a cytoplasmic molecule mediating Arp2/3 nucleated actin polymerization. Mice with a keratinocyte-specific deletion of the gene encoding N-WASP showed normal interfollicular epidermis, but delayed hair-follicle ... -
N-wave interactions related to simple lie algebras. ℤ2-reductions and soliton solutions
(IOP Publishing, 2001-07-23)The reductions of the integrable N-wave type equations solvable by the inverse scattering method with the generalized Zakharov-Shabat systems L and related to some simple Lie algebra g are analysed. The Zakharov-Shabat ... -
N=2 and N=4 subalgebras of super vertex operator algebras
(IOP Publishing, 2018-01-10)We develop criteria to decide if an N=2 or N=4 super conformal algebra is a subalgebra of a super vertex operator algebra in general, and of a super lattice theory in particular. We give some specific examples. -
Na Gaeil agus Iriseoireacht na nGael san Airgintín ag deireadh na Naoú hAoise Déag agus ag tús na Fichiú hAoise
(Acadamh na hOllscolaíochta Gaeilge, Ollscoil na hÉireann, Gaillimh, 2018)Chuaigh suas le 50,000 Éireannach go dtí an Airgintín sa tréimhse idir lár na naoú haoise déag agus an bhliain 1920. Luann Kelly (2009: 44) go raibh 36,800 duine a rugadh in Éirinn ag cur fúthu san Airgintín sa bhliain ... -
Naming my world: Finding my voice
(SAGE Publications, 2021-07-19)This is a personal account of a sociological career over four decades, influenced by developments in Irish society and sociology. I focus on the growth of a feminist sociology, the stigmatisation of unmarried mothers, ... -
Namur Citadel, 1695: A Case Study in Allied Siege Tactics
(SAGE Publications, 2011)Year after year Louis XIV's armies thrust through Brabant in the eastern part of the Spanish Netherlands, the biggest theatre of the Nine Years' War (1689-97). These thrusts followed the general line of the rivers Sambre ... -
Nano-sensitive optical coherence tomography
(Royal Society of Chemistry, 2014)Depth resolved label-free detection of structural changes with nanoscale sensitivity is an outstanding problem in the biological and physical sciences and has significant applications in both the fundamental research and ... -
Nano-textured self-assembled aligned collagen hydrogels promote directional neurite guidance and overcome inhibition by myelin associated glycoprotein
(Royal Society of Chemistry (RSC), 2011-01-01)The development of nerve guidance conduits is constantly evolving as the need arises for therapies for spinal cord injury. In addition to providing a path for regrowing axons to reconnect with their appropriate targets, ... -
Nano-textured self-assembled aligned collagen hydrogels promote directional neurite guidance and overcome inhibition by myelin associated glycoprotein
(Royal Society of Chemistry, 2011-01-11)The development of nerve guidance conduits is constantly evolving as the need arises for therapies for spinal cord injury. In addition to providing a path for regrowing axons to reconnect with their appropriate targets, ... -
Nanomaterials and biomaterials in electrochemical arrays for protein detection
(Royal Society of Chemistry (RSC), 2014-01-01)Nanomaterials and biomaterials are important components of new electrochemical arrays designed for sensitive detection of proteins in biological fluids. Such multiplexed protein arrays are predicted to have an important ... -
Nanoparticle generation during laser ablation and laser-induced liquefaction
(Elsevier BV, 2011-01-01)Recently short-pulse laser sources have been investigated as a potential method for nanoparticle synthesis. Deposited aluminium, nickel and gold nanoparticles generated during nano-and femto-second laser ablation were ... -
Nanoparticles in boreal forest and coastal environment: a comparison of observations and implications of the nucleation mechanism
(Copernicus GmbH, 2010-08-02)The detailed mechanism of secondary new particle formation in the atmosphere is still under debate. It is proposed that particle formation happens via activation of 1-2 nm atmospheric neutral molecular clusters and/or large ... -
Nanoscale mechanical characterisation of amyloid fibrils discovered in a natural adhesive
(Springer Nature, 2006-10-05)Using the atomic force microscope, we have investigated the nanoscale mechanical response of the attachment adhesive of the terrestrial alga Prasiola linearis (Prasiolales, Chlorophyta). We were able to locate and extend ... -
Nanoscale structure detection and monitoring of tumour growth with optical coherence tomography
(Royal Society of Chemistry, 2020-05-25)Approximately 90% of cancers originate in epithelial tissues leading to epithelial thickening, but the ultrastructural changes and underlying architecture are less well known. Depth resolved label free visualization of ... -
Nanosensitive optical coherence tomography for the study of changes in static and dynamic structures
(IOP Science, 2014-03-06)We briefly discuss the principle of image formation in Fourier domain optical coherence tomography (OCT). The theory of a new approach to improve dramatically the sensitivity of conventional OCT is described. The approach ...