Browsing University of Galway Support Services by Subject "budding yeast"

Now showing items 1-4 of 4

    • 53bp1: function and mechanisms of focal recruitment 

      FitzGerald, Jennifer E.; Grenon, Muriel; Lowndes, Noel F. (Portland Press Ltd., 2009-08-01)
      53BP1 (p53-binding protein 1) is classified as a mediator/adaptor of the DNA-damage response, and is recruited to nuclear structures termed foci following genotoxic insult. In the present paper, we review the functions of ...

    • Atr activates the s-m checkpoint during unperturbed growth to ensure sufficient replication prior to mitotic onset 

      Eykelenboom, John Kenneth; Harte, Emma Christina; Canavan, Lynn; Pastor-Peidro, Ana; Calvo-Asensio, Irene; Llorens-Agost, Marta; Lowndes, Noel Francis (Elsevier BV, 2013-11-01)
      Cells must accurately replicate and segregate their DNA once per cell cycle in order to successfully transmit genetic information. During S phase in the presence of agents that cause replication stress, ATR-dependent ...

    • Proteomics analysis with a nano random forest approach reveals novel functional interactions regulated by smc complexes on mitotic chromosomes 

      Ohta, Shinya; Montaño-Gutierrez, Luis F.; de Lima Alves, Flavia; Ogawa, Hiromi; Toramoto, Iyo; Sato, Nobuko; Morrison, Ciaran G.; Takeda, Shunichi; Hudson, Damien F.; Rappsilber, Juri; Earnshaw, William C. (American Society for Biochemistry & Molecular Biology (ASBMB), 2016-05-26)
      Packaging of DNA into condensed chromosomes during mitosis is essential for the faithful segregation of the genome into daughter nuclei. Although the structure and composition of mitotic chromosomes have been studied for ...

    • Sister chromatid cohesion and genome stability in vertebrate cells 

      Morrison, C.; Vagnarelli, P.; Sonoda, E.; Takeda, S.; Earnshaw, W.C. (Portland Press Ltd., 2003-02-01)
      For successful eukaryotic mitosis, sister chromatid pairs remain linked after replication until their kinetochores have been attached to opposite spindle poles by microtubules. This linkage is broken at the metaphase-anaphase ...