53bp1: function and mechanisms of focal recruitment

Thumbnail
View/Open
Full Text
Date
2009-08-01
Author
FitzGerald, Jennifer E.
Grenon, Muriel
Lowndes, Noel F.
Metadata
Show full item record
Usage
This item's downloads: 0 (view details)
Cited 102 times in Scopus (view citations)

Recommended Citation
FitzGerald, Jennifer E. Grenon, Muriel; Lowndes, Noel F. (2009). 53bp1: function and mechanisms of focal recruitment. Biochemical Society Transactions 37 , 897-904
Published Version
Abstract
53BP1 (p53-binding protein 1) is classified as a mediator/adaptor of the DNA-damage response, and is recruited to nuclear structures termed foci following genotoxic insult. In the present paper, we review the functions of S3BP1 in DNA-damage checkpoint activation and DNA repair, and the mechanisms of its recruitment and activation following DNA damage. We focus in particular on the role of covalent histone modifications in this process.
URI
http://hdl.handle.net/10379/11485
Collections