Browsing Research Institutes and Centres by Subject "Drug delivery"

Now showing items 1-3 of 3

    • Dynamic actuation enhances transport and extends therapeutic lifespan in an implantable drug delivery platform 

      Whyte, William; Goswami, Debkalpa; Wang, Sophie X.; Fan, Yiling; Ward, Niamh A.; Levey, Ruth E.; Beatty, Rachel; Robinson, Scott T.; Sheppard, Declan; O’Connor, Raymond; Monahan, David S.; Trask, Lesley; Mendez, Keegan L.; Varela, Claudia E.; Horvath, Markus A.; Wylie, Robert; O’Dwyer, Joanne; Domingo-Lopez, Daniel A.; Rothman, Arielle S.; Duffy, Garry P.; Dolan, Eimear B.; Roche, Ellen T. (Nature Research, 2022-08-03)
      Fibrous capsule (FC) formation, secondary to the foreign body response (FBR), impedes molecular transport and is detrimental to the long-term efficacy of implantable drug delivery devices, especially when tunable, temporal ...

    • In vitro attenuation of astrocyte activation and neuroinflammation through ibuprofen-doping of poly(3,4-ethylenedioxypyrrole) formulations 

      Krukiewicz, Katarzyna; Kowalik, Agnieszka; Turczyn, Roman; Biggs, Manus J. P. (Elsevier, 2020-04-08)
      Neuroinflammation is often associated with poor functional recovery and may contribute to or initiate the development of severe neurological disorders, such as epilepsy, Parkinson's disease or Alzheimer's disease. Ibuprofen ...

    • Local pharmacological induction of angiogenesis: drugs for cells and cells as drugs 

      Gaspar, Diana; Peixoto, Rita; De Pieri, Andrea; Striegl, Britta; Zeugolis, Dimitrios I.; Raghunath, Michael (Elsevier, 2019-06-19)
      The past decades have seen significant advances in pro-angiogenic strategies based on delivery of molecules and cells for conditions such as coronary artery disease, critical limb ischemia and stroke. Currently, three major ...