Browsing Research Institutes and Centres by Author "Samali, Afshin"
Now showing items 1-5 of 5
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Disruption of microRNA Biogenesis Confers Resistance to ER Stress-Induced Cell Death Upstream of the Mitochondrion
Samali, Afshin (2013)Global downregulation of microRNAs (miRNAs) is a common feature of human tumors and has been shown to enhance cancer progression. Several components of the miRNA biogenesis machinery (XPO5, DICER and TRBP) have been shown ... -
Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells
Samali, Afshin (2015)Endoplasmic reticulum (ER) stress-induced cellular dysfunction and death is associated with several human diseases. It has been widely reported that ER stress kills through activation of the intrinsic mitochondrial apoptotic ... -
Kinase Inhibitor against Quiescent and Proliferating CLL Cells
Natoni, Alessandro; Murill, Laura S.; Kliszczak, Anna E.; Samali, Afshin; Santocanale, Corrado (2011-07-18)In chronic lymphocytic leukemia (CLL) the proliferation rate and resistance to drug-induced apoptosis are recognized as important factors in the outcome of treatment. In this study, we assess the activity and the mechanism ... -
miRNA signature of unfolded protein response in H9c2 rat cardiomyoblasts
Samali, Afshin (2014)Background: Glucose and oxygen deprivation during ischemia is known to affect the homeostasis of the endoplasmic reticulum (ER) in ways predicted to activate the unfolded protein response (UPR). Activation of UPR signalling ... -
Resistance to TRAIL in non-transformed cells is due to multiple redundant pathways
Samali, Afshin (2013)Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a cytokine and a selective inducer of apoptosis in a range of tumour cells, but not in normal, untransformed cells. A large number of chemotherapeutics ...