Browsing Physiology by Title
Now showing items 59-73 of 73
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Preclinical evaluation of Millipede 088 intracranial aspiration catheter in cadaver and in vitro thrombectomy models
(BMJ Publishing Group, 2020-06-30)Background Larger bore aspiration catheters are expected to significantly improve the speed and completeness of acute stroke revascularization. Objective To evaluate the navigability and clot retrieval performance of a ... -
Prenatal exposure to valproic acid reduces social responses and alters mRNA levels of opioid receptor and pre-pro-peptide in discrete brain regions of adolescent and adult male rats
(Elsevier, 2020-01-21)Altered social behaviours are a hallmark of several psychiatric and developmental disorders. Clinical and preclinical data have demonstrated that prenatal exposure to valproic acid (VPA), an anti-epileptic and mood stabiliser, ... -
Psychological stress in early life as a predisposing factor for the development of chronic pain: Clinical and preclinical evidence and neurobiological mechanisms
(Wiley, 2016-07-12)A wealth of research over the past 2 decades has expanded our understanding of the impact of early-life adversity on physiological function and, consequently, health and wellbeing in later life. Early-life adversity increases ... -
Relationship between epithelial and stromal TRIM28 expression predicts survival in colorectal cancer patients
(Wiley, 2013-02-21)Background and Aim TRIM28 is a multi‐domain nuclear protein with pleotropic effects in both normal and tumor cells. In this study, TRIM28 expression in epithelial and stromal tumor microenvironment and its prognostic role ... -
A role for PPARα in the medial prefrontal cortex in formalin-evoked nociceptive responding in rats
(Wiley, 2013-12-05)Background and Purpose The nuclear hormone receptor, PPARα, and its endogenous ligands, are involved in pain modulation. PPARα is expressed in the medial prefrontal cortex (mPFC), a key brain region involved in both the ... -
S100b in acute ischemic stroke clots is a biomarker for post-thrombectomy intracranial hemorrhages
(Frontiers Media, 2023-01-23)Background and purpose: Post-thrombectomy intracranial hemorrhages (PTIH) are dangerous complications of acute ischemic stroke (AIS) following mechanical thrombectomy. We aimed to investigate if S100b levels in AIS clots ... -
Sex differences and similarities in depressive-and anxiety-like behaviour in the Wistar-Kyoto rat
(Elsevier, 2016-08-31)Depression is a debilitating psychiatric disorder that is highly comorbid with anxiety. Depression is twice as prevalent in women as in men, however, females remain underrepresented in preclinical research. The stress ... -
A standardized aspiration-first approach for thrombectomy to increase speed and improve recanalization rates
(American Society of Neuroradiology, 2019-08-14)BACKGROUND AND PURPOSE: Direct aspiration is a recognized technique for revascularization in large-vessel ischemic strokes. There is ongoing debate regarding its efficacy compared with stent retrievers. Every delay in ... -
Storage of blood clots for histological analysis: How long is too long in saline and paraformaldehyde?
(Universidad de Murcia, 2019)To investigate the composition of blood clots following mechanical thrombectomy, it is essential to ensure optimum storage for highest quality histological and immunofluorescence analysis. We investigated for how long clots ... -
Stromal TRIM28-associated signaling pathway modulation within the colorectal cancer microenvironment
(BMC (part of Springer Nature), 2018-04-10)Background Stromal gene expression patterns predict patient outcomes in colorectal cancer. TRIM28 is a transcriptional co-repressor that regulates an abundance of genes through the KRAB domain family of transcription ... -
Studying stroke thrombus composition after thrombectomy: What can we learn?
(Lippincott, Williams & Wilkins, 2021-09-14)The composition of ischemic stroke thrombi has gained an increasing amount of interest in recent years. The implementation of endovascular procedures in standard stroke care has granted researchers the unique opportunity ... -
These shoes are made for walking: sensitivity performance evaluation of commercial activity monitors under the expected conditions and circumstances required to achieve the international daily step goal of 10,000 steps
(Public Library of Science, 2016-05-11)IntroductionPhysical activity is a vitally important part of a healthy lifestyle, and is of major benefit to both physical and mental health. A daily step count of 10,000 steps is recommended globally to achieve an appropriate ... -
Time and region-dependent manner of increased brain derived neurotrophic factor and TrkB in rat brain after binge-like methamphetamine exposure
(Elsevier, 2019-11-03)Methamphetamine (MA), a synthetic derivate of amphetamine, has become a major drug of abuse worldwide. This study investigated the effect of binge-like MA dosing (4 x 4 mg/kg, s.c., 2 h (h) apart) at a range of different ... -
Ulk4 regulates GABAergic signaling and anxiety-related behavior
(Springer Nature, 2018-02-02)Excitation/inhibition imbalance has been proposed as a fundamental mechanism in the pathogenesis of neuropsychiatric and neurodevelopmental disorders, in which copy number variations of the Unc-51 like kinase 4 (ULK4) gene ... -
When a step is not a step! Specificity analysis of five physical activity monitors
(Public Library of Science, 2017-01-13)IntroductionPhysical activity is an essential aspect of a healthy lifestyle for both physical and mental health states. As step count is one of the most utilized measures for quantifying physical activity it is important ...