Studying stroke thrombus composition after thrombectomy: What can we learn?
Date
2021-09-14Author
Staessens, Senna
François, Olivier
Brinjikji, Waleed
Doyle, Karen M.
Vanacker, Peter
Andersson, Tommy
De Meyer, Simon F.
Metadata
Show full item recordUsage
This item's downloads: 77 (view details)
Cited 2 times in Scopus (view citations)
Recommended Citation
Staessens, Senna, François, Olivier, Brinjikji, Waleed, Doyle, Karen M., Vanacker, Peter, Andersson, Tommy, & Meyer, Simon F. De. (2021). Studying Stroke Thrombus Composition After Thrombectomy: What Can We Learn? Stroke, 52(11), 3718-3727. doi:doi:10.1161/STROKEAHA.121.034289
Published Version
Abstract
The composition of ischemic stroke thrombi has gained an increasing amount of interest in recent years. The implementation of endovascular procedures in standard stroke care has granted researchers the unique opportunity to examine patient thrombus material. Increasing evidence indicates that stroke thrombi are complex and heterogenous, consisting of various biochemical (eg, fibrin, von Willebrand Factor, and neutrophil extracellular traps) and cellular (eg, red blood cells, platelets, leukocytes, and bacteria) components. This complex composition may explain therapeutic limitations and also offer novel insights in several aspects of stroke management. Better understanding of thrombus characteristics could, therefore, potentially lead to improvements in the management of patients with stroke. In this review, we provide a comprehensive overview of the lessons learned by examining stroke thrombus composition after endovascular thrombectomy and its potential relevance for thrombectomy success rates, thrombolysis, clinical outcomes, stroke etiology, and radiological imaging.