Browsing University of Galway Theses by Author "SFI"
Now showing items 1-20 of 34
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Advances in Understanding, Mining, and Using People-Tags
Nasirifard, Peyman (2012-05-31)People-tagging involves the process of adding non-hierarchical metadata to users of a system. Such metadata facilitates organising contacts and building user profiles in a collaborative fashion. People-tag-based user ... -
The anomerisation of glycosyl thiols and synthesis of multivalent GlcNAc and GalNAc glycoclusters
O'Sullivan, Shane (2015-04-29)There are several published procedures available for the synthesis of b-thiopyranoses such as gluco- or galacto-pyranoses. Given the ease with which one can access such b -thiopyranoses, the development of a reproducible ... -
An autoignition study of hydrogen and natural gas mixtures under gas turbine relevant conditions in a rapid compression machine
Donohoe, Nicola (2013-11-14)This study presents an experimental and modelling investigation of the ignition of hydrogen and natural gas mixtures. These mixtures were chosen due to their relevancy to the gas turbine industry. A detailed chemical ... -
Biochemical and functional characterization of human MSL2
Moravcova, Simona (2013-04-10)DNA in Eukaryotic cells is complexed with histone proteins to form chromatin. This mediates DNA packaging into the nucleus but also facilitates the regulation of all DNA-templated processes, including transcription, ... -
Cellular response to stress: role of autophagy and cell death in caspase-9 deficient cells
Pakos-Zebrucka, Karolina (2017-10-31)Chronic or unresolved stress can lead to cell death, and induction of apoptosis is crucial when the cellular adaptive mechanisms are not able to resolve persistent stress. Malfunction of the apoptotic process caused by ... -
Characterization of PIWI+ stem cells in Hydractinia
McMahon, Emma (2018-02-23)Hydractinia is a colonial marine invertebrate and a member of the phylum Cnidaria. It represents a very powerful tool for studying basic developmental biology and differentiation due to the presence of a population of stem ... -
Chromatic Aberrations in Optical Systems: Prediction and Correction
Bahrami, Mehdi (2012-12-19)The variation of refractive index with wavelength, known as dispersion, was what redirected Isaac Newton from refractive telescope designs toward a reflective one, since he found the chromatic effect incurable. Later it ... -
Computational design of glycomimetic inhibitors of Influenza A Adhesion
Smith, Hannah Mary Kate (2015-02-16)Many pathogens, such as avian influenza, Helicobacter pylori and Streptococcus pneumoniae, employ cell-surface glycans which terminate in Neu5AcAlpha(2-3)Gal as their adhesion partner.[1] As a result, a glycomimetic ... -
The Design and Evaluation of Graphical Radial Menus
Samp, Krystian (2011-12-05)Graphical menus provide slow performance and yet users often try to select menu commands as fast as possible. Shortcut techniques that enable users to by-pass selections from a graphical menu are fast, but are not the ... -
Development of transgenic and genome editing tools to study the role of Notch signalling in Hydractinia echinata
Gahan, James (2016)Hydractinia is a colony forming marine invertebrate and a member of the phylum Cnidaria. Members of this genus have been models for developmental biologists for over a century and feature many characters of evolutionary ... -
The Effects of Biomedical Signal Compression in Wireless Ambulatory Healthcare
Higgins, Garreth (2013-10-30)This thesis seeks to contribute to the field of ambulatory healthcare by examining methodologies to minimise the size of bioelectric signals, whilst preserving the quality of the diagnostic information contained within ... -
Ex-vivo generation of regulatory T-cells expressing transcription factor foxp3 and their application in cornea transplantation
Maenz, Martin (2011-05-27)This project investigated the therapeutic potential of allo-antigen specific regulatory T-cells in the context of penetrating keratoplasty. Two methods of ex-vivo generation of T regulatory cells have been explored in ... -
Fibrin Mediated Proangiogenic and Secretory Control Gene Therapy for Compromised Wound Healing
Kulkarni, Mangesh (2012-07-18)Chronic or compromised healing is a major clinical problem. Particularly, in diabetes where the disease process hinders the capacity to repair the tissue damage, the patients are more susceptible to chronic ulcers, especially ... -
Functional role of CCAN histone fold proteins in mitosis
Kaczmarczyk, Agnieszka (2012-05-31)Centromeres are chromosomal loci that direct segregation of the genome by specifying kinetochore assembly in mitosis and meiosis. Kinetochores are built upon centromeric chromatin, which contains the histone H3 variant ... -
Genome dosage and parent of origin effects in a ploidy series of Arabidopsis thaliana
Antoine, Fort (2013-11-11)Polyploidy, the presence of more than two sets of chromosomes in an organism, plays major roles in plant evolution, development and function. Understanding the effects of polyploidization at the phenotypic and molecular ... -
Glycosaminoglycan Dependent Isolation of Mesenchymal Chondroprogenitor Populations from Human Bone Marrow
O'Sullivan, Janice (2013-01-24)Osteoarthritis (OA) is a chronic disease of joints characterised by progressive destruction of articular cartilage resulting in painful, limited joint movement. Cartilage has a limited ability to self-repair due to low ... -
Hardware spiking neural network and remote FPGA lab
Cawley, Seamus (2013-02-22)The automatic design of intelligent systems has been inspired by biology, specifically the operation of the human brain. Researchers hope to exploit and replicate the brain's ability to adapt and self repair in order to ... -
hMOF and associated proteins in transcription and cancer
Clasen, Sandra (2013-04-24)The lysine acetyltransferase MOF (males absent on the first) has been associated with transcriptional activation in Drosophila melanogaster. This activation is mediated by its acetylation of histone H4 at lysine 16 ... -
An Infrastructure for Privacy-Enabled Sharing of Context Data
Hynes, Gearoid (2011-08-29)The concept of context originated in the ubiquitous computing domain where information regarding the user's situation was gathered using sensing devices, allowing the application to automatically adapt according to the ... -
Investigating the role of the endogenous cannabinoid system in emotional modulation of pain: neurochemical and molecular mechanisms
Olango, Weredeselam Menna (2012-03-24)Abstract Pain represents a major unmet clinical need and affects a large number of individuals worldwide. The modulation of pain by cognitive and emotional factors is now widely recognised. Increased understanding of the ...