Browsing University of Galway Theses by Subject "Chondrocyte"
Now showing items 1-3 of 3
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Allogeneic cell therapy for osteoarthritis
(2016-05-11)Osteoarthritis is a debilitating multi-factorial joint disease which currently has no cure. Due to the significant immune cell mediated component in this disease a therapy which can modulate this inflammation and promote ... -
Evaluation of human induced pluripotent stem cell-based cellular models for pathological investigation of genetic skeletal diseases
(NUI Galway, 2019-02-15)The uniqueness of stem cells endows them with the capacity to be used as a valuable tool in the field of pathology, particularly the one from patients. Patient-specific cellular model can be generated by deriving donor-specific ... -
The Role of the Actin Cytoskeleton in the Response of Chondrocytes to Mechanical Loading: A Computational and Experimental Investigation
(2012-09-28)The biomechanisms which govern the response of chondrocytes to mechanical stimuli are poorly understood. This thesis aims to provide a more in depth understanding of chondrocyte biomechanics by focusing on the role of actin ...