Browsing University of Galway Theses by Subject "Translesion synthesis"
Now showing items 1-2 of 2
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Characterisation of UVA-induced DNA damage responses in human skin cells
(2013-09-30)Accumulating evidence indicates that exposure to long-wavelength ultraviolet A (UVA) radiation (315-400 nm), which accounts for >95% of solar UV radiation reaching the earth's surface, is a significant risk factor for the ... -
Roles of DNA polymerase eta and replication protein A (RPA) in undamaged and platinum-treated human cells
(2012-09-28)Platinum-based drugs are widely used in cancer therapy. Bypass of platinum-induced DNA adducts during DNA replication by specialised DNA polymerases may contribute to drug tolerance and tumour cell resistance. Human cells ...