Browsing University of Galway Theses by Subject "Parkinson's disease"
Now showing items 1-6 of 6
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The cannabinoid type-2 (CB2) receptor as a target for anti-inflammatory disease modification in Parkinson's disease
(2016-08-04)Parkinson’s disease is a multifaceted neurodegenerative disorder with no curative treatment. A key aspect in the pathogenesis of Parkinson’s disease is inflammation, which is initially triggered by dying neurons and which ... -
A glyco approach for the treatment of Parkinson’s disease: From the glycobiological characterisation to the development of glyco-modulatory collagen-based hydrogel systems
(NUI Galway, 2021-12-20)Parkinson’s disease (PD) is the most common motor-related progressive neurodegenerative condition, mainly caused by the loss of dopaminergic neurons in the substantia nigra. Despite the increased knowledge regarding its ... -
Investigating the potential of targeting the CB2 receptor for anti-inflammatory disease modification in Parkinson’s disease
(NUI Galway, 2021-10-22)Parkinson’s disease is a multifaceted neurodegenerative disorder that currently has no cure. Chronic neuroinflammation is thought to play a crucial role in the progression of the disease, with neuroinflammation and ... -
The potential of GDF5-functionalised collagen hydrogels to enhance dopaminergic cell replacement therapies for Parkinson's disease
(NUI Galway, 2020-03-05)Parkinson’s disease is a progressive neurodegenerative disorder associated with the loss of dopaminergic neurons from the substantia nigra and striatum. Over time, the gold standard pharmacotherapy, L-dopa, loses its ... -
The potential of neurotrophin-secreting mesenchymal stem cells for the treatment of Parkinson's disease
(2015-06-30)The most effective experimental neuroprotectant for Parkinson's disease that has been identified from extensive preclinical studies is the neurotrophin, glial cell line-derived neurotrophic factor (GDNF). However, the ... -
Prodromal Parkinson’s disease, DOPAL and the olfactory bulb: from an organotypic model to clinical relevance
(NUI Galway, 2020-09)Parkinson’s disease (PD) is an untreatable neurodegenerative disorder affecting more than six million people worldwide, a figure expected to more than double within a generation. The causes of PD are still largely unknown ...