Browsing University of Galway Theses by Subject "Next-generation sequencing"
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Identification and characterisation of germline variants in an Irish cohort with breast cancer
(NUI Galway, 2020-02-10)Breast cancer is the most common female malignancy worldwide, and the second most common cause of cancer-related deaths in women. Twin studies estimate that up to one third of breast cancers are the result of hereditary ... -
Machine learning and high-performance computing: Infrastructure and algorithms for the genome-scale study of genetic and epigenetic regulatory mechanisms with applications in neuroscience
(2014-06-30)The advent of next-generation sequencing (NGS) has fundamentally changed modern genomics re-search. These sequencers generate terabytes of data and necessitate the use, not only of high-performance compute (HPC) clusters ...