Browsing University of Galway Theses by Subject "Glycosylation"
Now showing items 1-10 of 10
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Development and characterisation of recognition molecules for the specific identification of non-human glycans
(2015-01-26)Glycosylation is an enzymatic process through which glycans attach to proteins, lipids and other organic molecules with huge structural diversity. This is a common post-translational modification found on proteins and cell ... -
Exploring the role of glycosylation in vascular biology, immunology,and stem cell biology
(2016-09-30)Carbohydrates are important modulators in various biological and physiological processes. They are present ubiquitously and coat all cells, forming the glycocalyx of the cell. Glycosylation, a type of post-translational ... -
A glyco approach for the treatment of Parkinson’s disease: From the glycobiological characterisation to the development of glyco-modulatory collagen-based hydrogel systems
(NUI Galway, 2021-12-20)Parkinson’s disease (PD) is the most common motor-related progressive neurodegenerative condition, mainly caused by the loss of dopaminergic neurons in the substantia nigra. Despite the increased knowledge regarding its ... -
Glycosylation and glycoengineering of recombinant antibody fragments in Escherichia coli
(2016-11-14)Recombinant protein production (RPP) in Escherichia coli benefits from a long history of research which has facilitated the development of a plethora of strains and vectors suited to RPP applications. The identification ... -
Glycosylation in the injured and regenerating spinal cord, and the influence of biomaterial treatment
(NUI Galway, 2020-02-04)Traumatic spinal cord injury (SCI) results in disruption of tissue integrity leading to a loss of function. There has been minimal success in treating these injuries clinically, due to the inhibitory environment which ... -
Multiple myeloma: The role of glycosylation in disease development and progression.
(2017-09-09)Multiple myeloma (MM) is a clonal plasma cell disorder that is characterized by skeletal destruction, renal failure, anaemia and hypercalcaemia. MM cells are intimately associated with the bone marrow microenvironment, ... -
N- and O- linked Glycosylation, Developing Mass Spectrometric Strategies for the Characterisation of Glyco-epitopes
(2012-12-10)The overall goal of this thesis was to adopt a liquid chromatography-mass spectrometry (LC-MS) platform for glycomic analysis of glycoproteins. In particular we were interested in characterizing complex glycomic samples ... -
The role of glycosylation in intervertebral disc degeneration: Towards glyco-functionalised therapeutics
(NUI Galway, 2021-09-24)Low back pain (LBP) is a common health issue that imposes a significant socio-economic burden on society. Primarily, intervertebral disc degeneration is one of the major contributing causes of LBP. It is initiated by altered ... -
The role of glycosylation in regulatory T-cell biology
(2016-12-14)Regulatory T-cells (T-reg) play a pivotal role in maintaining immune homeostasis and tolerance. There has been a significant amount of research devoted to understanding their physiological mechanisms of action and the ... -
Targeting the glycome of major milk proteins
(2016-10-20)The objectives of this thesis were to 1) explore the glycosylation of major bovine milk proteins, 2) investigate the effect of lactational stage on glycan structures and 3) examine how these documented changes may influence ...