Browsing University of Galway Theses by Subject "Breast cancer"
Now showing items 1-20 of 26
-
Analysis of cytokine expression in breast cancer
(2014-10-29)Introduction: It has long been recognized that cancer develops in sites of chronic inflammation. Tumours seem to seize molecular pathways seen in wound healing and the inflammatory response and as a consequence appear as ... -
A biological and pharmacological investigation of the unfolded protein response in models of breast cancer
(NUI Galway, 2020-11-20)Breast cancer is the most common malignancy in women worldwide. At the molecular level, breast cancer is a heterogeneous disease. For example, the claudin low subtype of breast cancer is characterised by epithelial-mesenchymal ... -
Confocal microwave imaging and artifact removal algorithms for the early detection of breast cancer
(NUI Galway, 2018-03-29)Microwave imaging is an emerging imaging modality for the early detection of breast cancer. Early-time artifact removal and imaging algorithm are the two most important signal processing components of any Confocal Microwave ... -
Economic explorations of equality issues across the care pathway in breast cancer
(2015-02-10)Breast cancer places a high burden on the health system and on society as a whole. Incidence has been on the increase in recent decades and is projected to continue increasing in the coming years. There are constant advances ... -
An Evaluation of the Influence of Perceptions of Breast Cancer on Distress in Irish Women
(2013-04-15)Breast cancer is the most common form of invasive cancer diagnosed in women in Ireland. It can cause distress in healthy women considering their risk of developing the disease, as well as in women who have been diagnosed ... -
Exosome-encapsulated microRNAs as circulating biomarkers for breast cancer
(2016-06-15)Breast cancer is a heterogeneous group of diseases survival from which depends on stage at diagnosis. The development of blood-based biomarkers which may facilitate earlier detection and possibly subtype delineation remains ... -
Factors influencing diagnosis and outcome in HER2 receptor positive breast cancer
(NUI Galway, 2019-02-22)Introduction About 30% of breast cancers are HER2 receptor positive, these breast cancers traditionally had a poor prognosis but the introduction of targeted anti-HER2 therapy (Trastuzumab) has resulted in a vast improvement ... -
Identification and characterisation of germline variants in an Irish cohort with breast cancer
(NUI Galway, 2020-02-10)Breast cancer is the most common female malignancy worldwide, and the second most common cause of cancer-related deaths in women. Twin studies estimate that up to one third of breast cancers are the result of hereditary ... -
Integration of Genetic Biomarkers in Prognostic Models for Breast Cancer Survival
(2014-01-08)The main aim of my PhD is to create a prognostic model for invasive breast cancer patients for disease recurrence and death. The data were collected retrospectively and are comprised of 647 invasive breast cancer patients ... -
Investigating the impact of genomic profiling on breast cancer risk prediction, treatment and outcome
(2018-02-05)It has, for many years, been acknowledged that “breast cancer” is an umbrella term for many genetically and immunophenotypically distinct malignancies of the breast. Treatment paradigms are shifting in direct response to ... -
Investigating the role of IRE1α RNase activity in breast cancer
(NUI Galway, 2018-12-17)Metastatic, drug resistant disease poses the greatest threat to the survival of breast cancer patients. Thus, elucidating and targeting mechanisms which govern this phenotype is a primary goal of the breast cancer field. ... -
Investigation of IRE1/XBP1s pathway and its potential as a therapeutic target in breast cancer
(2015-09-18)X-Box binding protein 1 (XBP1) is an integral component of the unfolded protein response (UPR), a pro-survival mechanism, triggered by the onset of endoplasmic reticulum stress. Activation of the endoplasmic reticulum ... -
Investigation of metallacarboranes as unexpected therapeutics against triple-negative breast cancer cells
(NUI Galway, 2023-10-03)Metallacarboranes have been shown to have very promising properties for biomedical applications, with some derivatives having already shown good results in a number of cancer subtypes. The ability to self-aggregate, ... -
The lysine acetyltransferase MOF: its interactome, role in breast cancer, and characterisation of a novel isoform
(2017-11-24)Males absent on the first (MOF), also known as hMOF, MYST1, or KAT8, is a lysine acetyltransferase responsible for bulk acetylation of Histone H4 at lysine 16 (H4K16ac), though it has also been shown to acetylate several ... -
Mastectomy and breast reconstruction in the modern era: the role of neoadjuvant therapies and regenerative surgery
(NUI Galway, 2018-10-09)Complete surgical resection with disease free margins remains the cornerstone of effective breast cancer treatment. Breast cancer management continues to evolve with the development of more sophisticated techniques of ... -
Meseanchymal stem cell mediated sodium iodide symporter gene therapy of breast cancer
(2014-05-07)Introduction: The Sodium Iodide Symporter (NIS) facilitates iodide accumulation in the thyroid and radioiodide imaging and treatment of thyroid disease. Studies have suggested that elevated levels of NIS expression in ... -
microRNA-mediated intercellular communication in the primary breast tumour microenvironment
(2014-08-30)microRNAs (miRNA) have been highlighted as potential circulating biomarkers and as therapeutic targets for breast cancer. Recent evidence suggests that miRNAs are transported in protective microvesicles called exosomes, ... -
MiRNAs as oncologic biomarkers for breast cancer
(2014-08-18)Understanding of the molecular complexity underlying breast cancer has greatly advanced in recent years. Distinct phenotypic subtypes have been identified each of which carry prognostic and predictive implications. Despite ... -
Molecular mechanisms and tumour heterogeneity in breast cancer
(2014-05-07)MicroRNAs play a critical role in regulation of gene expression and are known to be dysregulated in breast cancer. The aim of this study was investigate four microRNAs miR-875-5p, miR-339-5p, miR-10a and miR-379 which were ... -
Multi-omics analysis reveals novel roles for IRE1α in triple negative breast cancer (TNBC)
(NUI Galway, 2021-09-07)Constitutive aberrant IRE1α signalling has been previously reported in triple negative breast cancer (TNBC), where is suggested to contribute to the disease progression and therapy resistance. Despite its clinical relevance, ...