Browsing University of Galway Theses by Author "O'Dwyer, Michael"
Now showing items 1-3 of 3
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Disruption of NEDD8 protein conjugation as a novel therapy for acute myeloid leukemia
Swords, Ronan (2012-08-15)The coordinated balance between the synthesis and degradation of proteins is an important regulator of cancer cell biology. The ubiquitin-proteasome system (UPS) is responsible for the timed destruction of many proteins ... -
Examining a new class of dual CDC7/CDK9 inhibitors, mechanisms of proliferation, and proliferation-based stratification in myeloma
Coyne, Mark Robert (2014-09-05)A key feature of progressive myeloma is a relative increase in proliferation. The DBF4-dependent kinase (DDK), cell division cycle 7 (CDC7), is an essential kinase for initiation of DNA replication. This thesis assesses ... -
An investigation of the role of the hypersialylated myeloma cell surface in facilitating evasion of natural killer cell-mediated immunosurveillance
Daly, John (NUI Galway, 2021-12-30)Abnormal glycosylation is a hallmark of cancer, and hypersialylation in particular has been shown to facilitate abnormal cell trafficking and drug resistance in many cancers, including Multiple Myeloma (MM) - a currently ...