Browsing University of Galway Theses by Author "Morrison, Ciaran"
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Centrobin functions in centriole duplication, primary ciliogenesis and genome maintenance
Adesanya, Yetunde (2018-03-06)The centrosome is composed of numerous proteins that make up its core structure. Other proteins also transiently localise and interact with centrosomal proteins for functional modulation. Centrobin, one of the core centrosomal ... -
The control of centrosome duplication after genotoxic stress
Inanc, Burcu (2011-12-16)The centrosome is the major microtubule organising center in animal cells. Following DNA damage, centrosome amplification can occur, which in turn can result in the formation of multipolar mitotic cells, and cell death. ... -
Functional dissection of the Smc5/6 complex: roles of the SUMO ligase Nse2/Mms21 in the maintenance of genome stability
Kliszczak, Maciej (2011-06)Nse2/ Mms21 is an E3 SUMO ligase component of the Smc5/6 complex, which plays multiple roles in maintaining genome stability. To study the functions of the vertebrate Nse2 orthologue, we generated Nse2-deficient chicken ... -
Impacts of DNA damage on the pericentriolar material and centriole duplication
Mullee, Lisa (2015-12-03)The centrosome consists of two barrel-shaped centrioles embedded in a proteinaceous pericentriolar material (PCM), a highly organised scaffold that serves as a platform for proteins that regulate spindle assembly, protein ... -
The primary cilium as a regulator of cellular senescence in human fibroblasts
Breslin, Loretta (2014-02-11)Somatic cells senesce in culture after a finite number of divisions, indefinitely arresting their proliferation. Among the major causes of senescence is persistent DNA damage signalling. DNA damage and senescence increase ... -
Reverse genetic analysis of Cep164 in vertebrates
Daly, Owen (2016-05-12)Components of the centrosome have been reported to have a role in the DNA Damage Response (DDR) pathway. Cep164, a protein localised to the distal appendages of centrioles, is theorised to play a part in the DDR. As with ... -
The roles of centrins/caltractins at the centrosome and in genome maintenance
Dantas, Tiago Jorge O.G. de Almeida (2012-06-21)The principal microtubule-organising centre in animal cells, the centrosome, contains centrin, a small, highly-conserved calcium-binding protein that can be found throughout eukaryotes. Several centrin isoforms exist and ... -
Understanding the multifunctional domains of controller protein Centrin2
Khouj, Ebtissal (NUI Galway, 2018-12-21)Centrin2 is a centrosomal calcium-binding protein that plays a critical role in centriole dynamics and ciliogenesis. Structurally, it has four calcium-binding EF- hand motifs. Most of the cellular centrin2 is not associated ...