Browsing University of Galway Theses by Author "Hardiman Research Scholarship, NUI Galway"
Now showing items 1-6 of 6
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Characterisation of human nucleolar organisers located in previously uncharted regions of the human genome
Ó Gailín, Michael (NUI Galway, 2019-01-18)The nucleolus is a large, sub-nuclear domain and the site of ribosome biogenesis. Nucleoli form around chromosomal loci called ‘nucleolar organiser regions (NORs) located on the short arms of the human acrocentric ... -
Development of drugs targeting the human tRNA ligase RtcB in breast cancer
Nandy, Argha (NUI Galway, 2019-02-15)The RNA ligase RtcB has been shown to regulate RNA function by direct exon ligation of spliced XBP1 messenger RNA cleaved by the endoplasmic reticulum (ER) stress sensor IRE1α. Ligation by RtcB leads to the expression of ... -
Epigenetic regulation of NOD-like receptor activity and expression
Feerick, Claire L. (NUI Galway, 2018-11-19)NOD-like receptors (NLRs) are a family of intracellular pathogen recognition receptors involved in the innate immune response. NOD1 and NOD2 are the best characterised members of this family, and so are the focus of this ... -
Integrative evaluation of Tetanocera elata (Diptera: Sciomyzidae) for slug pest management in agriculture
Bistline-East, Allison (NUI Galway, 2019-09-25)Terrestrial gastropods are pervasive pests, especially of agriculture in temperate regions. While current management options exist, they primarily consist of baited pellets with active ingredients such as methiocarb or ... -
Regulation of cell fate by microRNAs during unfolded protein response and its role in cancer
Arabkari, Vahid (NUI Galway, 2018-12-20)The endoplasmic reticulum (EnR) stress is a common phenomenon in various cancers such as breast, colorectal, skin and hepatocellular carcinoma. Several pathophysiological events (e.g., radiation, aneuploidy, oncogenic ... -
A thermodynamically motivated investigation of cell and tissue remodelling
McEvoy, Eóin (NUI Galway, 2018-08-24)The overall objective of this thesis is to provide a new understanding of the mechanisms that drive cell spreading and remodelling, and to extend this understanding to remodelling at a tissue and organ level. A steady-state ...