Browsing University of Galway Theses by Author "Gorman, Adrienne"
Now showing items 1-12 of 12
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A biological and pharmacological investigation of the unfolded protein response in models of breast cancer
Leuzzi, Brian (NUI Galway, 2020-11-20)Breast cancer is the most common malignancy in women worldwide. At the molecular level, breast cancer is a heterogeneous disease. For example, the claudin low subtype of breast cancer is characterised by epithelial-mesenchymal ... -
A cell-based study exploring novel therapeutic approaches to target cell stress and cell death pathways in paediatric cancers
McCarthy, Nicole (NUI Galway, 2020-08-17)Paediatric cancer is the leading cause of death by disease in children. High mortality rates and long-term effects of conventional treatments suggest an urgent need for basic and translational research to allow treatment ... -
Cellular response to stress: role of autophagy and cell death in caspase-9 deficient cells
Pakos-Zebrucka, Karolina (2017-10-31)Chronic or unresolved stress can lead to cell death, and induction of apoptosis is crucial when the cellular adaptive mechanisms are not able to resolve persistent stress. Malfunction of the apoptotic process caused by ... -
Characterization of a novel cell death-inducing protein complex assembled in response to stress
Glogowska, Izabela (NUI Galway, 2021-01-26)Pro-caspase-8 is the apical caspase in the extrinsic apoptosis which is initiated by the external stimulation of certain death receptors. Pro-caspase-8 is synthesised as an inactive zymogen, which must be cleaved to reach ... -
Development of a novel companion diagnostic for IRE1α activity and its application to investigate the role of IRE1α in acute myeloid leukaemia cells
Creedican, Stuart (NUI Galway, 2020-08-28)The unfolded protein response (UPR) is an evolutionarily conserved mechanism activated in response to accumulation of unfolded protein (termed ER stress). Activation of the UPR is observed during many physiological processes ... -
Development of drugs targeting the human tRNA ligase RtcB in breast cancer
Nandy, Argha (NUI Galway, 2019-02-15)The RNA ligase RtcB has been shown to regulate RNA function by direct exon ligation of spliced XBP1 messenger RNA cleaved by the endoplasmic reticulum (ER) stress sensor IRE1α. Ligation by RtcB leads to the expression of ... -
Identification and validation of novel targets of regulated IRE1-dependent decay in triple negative breast cancer
Bolger, Alice (NUI Galway, 2023-08-16)Breast cancer is the most commonly diagnosed cancer in women. Triple-negative breast cancer (TNBC) refers to a subtype which lacks oestrogen receptors (ESR1), progesterone receptors (PR) and does not overexpress Human ... -
Multi-omics analysis reveals novel roles for IRE1α in triple negative breast cancer (TNBC)
Almanza Goikoetxea, Aitor (NUI Galway, 2021-09-07)Constitutive aberrant IRE1α signalling has been previously reported in triple negative breast cancer (TNBC), where is suggested to contribute to the disease progression and therapy resistance. Despite its clinical relevance, ... -
Neurotrophic signalling and inhibition in breast cancer and chronic lymphocytic leukaemia
Hillis, Jennifer (2016-01-15)Neurotrophins are important growth factors for neuronal cells. They interact with the Trk kinase receptors and the p75NTR receptor to induce several signaling pathways. Neurotrophins and their receptors are known regulators ... -
NGF-induced pro-survivla signalling: Molecular engineering of NGFto enhance pro-survival signalling
Carleton, Laura (2014-01-27)Nerve growth factor (NGF) is a potent pro-survival growth factor that has diverse roles in development and in the adult nervous system. It has two cognate receptors that stimulate distinct signalling pathways, tropomyosin-related ... -
NGF/p75NTR or HSPB1-mediated regulation of cell survival under stress
Chakravarthy, Reka (2016-02-09)Triple negative breast cancers (TNBC) lack estrogen, progesterone and HER-2 receptors rendering them insensitive to current hormone targeted therapies. However, TNBC have been reported to express and secrete an additional ... -
Pro-survival pathways in triple negative breast cancer: Focus on the roles of RIP2 and HSPB1
Jaafar, Rola (2016-10-10)Triple negative breast cancers (TNBC) lack estrogen and progesterone receptors, and HER-2 markers rendering them resistant to current targeted therapies. Most TNBCs show basal-like characteristics and the terms TNBC and ...