Browsing University of Galway Theses by Title
Now showing items 1375-1394 of 2276
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Meseanchymal stem cell mediated sodium iodide symporter gene therapy of breast cancer
(2014-05-07)Introduction: The Sodium Iodide Symporter (NIS) facilitates iodide accumulation in the thyroid and radioiodide imaging and treatment of thyroid disease. Studies have suggested that elevated levels of NIS expression in ... -
Mesenchymal stem cell mediated delivery of Extracellular Vesicle (EV)-encapsulated microRNAs for the treatment of breast cancer
(NUI Galway, 2020-08-04)Mesenchymal Stem Cells (MSCs) hold the ability to home to the site of the tumour and bypass the host immune system. Extracellular Vesicles (EVs) are thought to be a fingerprint of the parent cell and therefore MSC-EVs ... -
Mesenchymal stem cells for therapeutic application in corneal transplantation
(2014-02-12)Although corneal transplantation success rates are high within the first year, the prognosis is much less favourable 5 years post-transplantation with immune-mediated rejection the primary cause of allograft failure. For ... -
Mesenchymal stromal cells: their immunosuppressive capacity and protein production profile
(2016-08)The clinical benefits of mesenchymal stromal cell (MSC) based therapies for immune disorders and degenerative diseases are based on their combined ability to modulate the immune system and to differentiate into different ... -
Metal removal and recovery from zinc refinery residue using microbiologically produced elemental chalcogen nanoparticles
(NUI Galway, 2022-09-20)This research aimed at investigating the application of elemental chalcogen nanoparticles for the removal of metals from wastewaters. In the first part of the study, biogenic (Bio) selenium nanoparticles (SeNPs) were ... -
Metal-based dithiocarbamato glycoconjugates: a suitable strategy to target tumour glycolysis?
(NUI Galway, 2019-03-11)Rapidly dividing tumour cells require higher amounts of nutrients and energy for their fast proliferation, and glucose is no exception (the so-called “Warburg effect”). Consequently, such increased demand of glucose by ... -
Metal-based glycoconjugates as molecular sensors for lectins and anti-adhesives
(NUI Galway, 2024-04-05)The anti-microbial resistance crisis has been inexorably developing at ever more alarming levels in the 21st century. The WHO regularly updates a list of bacterial and fungal critical priority pathogens for which new ... -
Metal-based glycoconjugates for the targeted anticancer chemotherapy
(NUI Galway, 2023-08-30)Rapidly dividing tumor cells require higher amounts of nutrients and energy to sustain their abnormal proliferation rates, and glucose is no exception. Glucose enters the cell by facilitated diffusion through the glucose ... -
Metal-based theranostic and therapeutic agents for the targeted treatment and imaging of tumors
(NUI Galway, 2024-01-12)The present PhD thesis resulted from the undertaking of two separate research projects, both anyway being strictly related to the rational design of metal complexes with potential therapeutic and/or diagnostic ... -
Metaphor processing in tweets
(NUI Galway, 2021-03-15)Metaphor plays an important role in defining the interplay between cognition and language. Despite its fuzziness, this ubiquitous figurative device is an essential element of human communication that allows us (as humans) ... -
Metastatic breast cancer: Patterns of metastasis and novel biomarkers
(NUI Galway, 2018-05-25)Breast cancer is a heterogeneous disease and is the leading cause of cancer-related deaths among women, with metastatic disease the principle cause of mortality. In recent years great advances have been made in stratifying ... -
Methamphetamine exposure during pregnancy: Neurodevelopmental consequences for the offspring
(2016-04-05)Methamphetamine (MA) abuse during pregnancy is a significant concern worldwide. Improving our understanding of the consequences of such exposure on the child is paramount and animal models provide an alternative method of ... -
Methods for defining dynamic online communities and community detection in fast-paced social media streams
(NUI Galway, 2019-05-02)Microblogging social media focuses on fast open real-time communication using short messages between users and their followers. Twitter is currently one of the largest and widely known microblogging OSN in the world, with ... -
Methods for improving the efficiency of high-performance audio amplifiers
(NUI Galway, 2022-05-23)High-performance class-D audio amplifiers have seen application in many modern consumer electronic devices including smartphones, wireless speakers and headphones, laptops, TVs, etc. While the efficiency and size of modern ... -
Methods of disseminating and translating research findings to health care professionals and other stakeholders
(NUI Galway, 2019-05-10)There are many barriers to the uptake of research findings including information overload, a lack of health literacy skills, a lack of access to research resources. Knowledge translation and dissemination and implementation ... -
A micro economic investigation of Irish cattle farmer decisions in response to non-linear budget constraints
(2016-07)This thesis will examine the effects of policy developments on the Irish beef sector, with a particular focus on agricultural subsidy payments. As a member of the European Union, Irish agriculture is governed by the Common ... -
The micro-institutional dynamics of entrepreneurship in the university
(2014-10-30)This study explores how micro-institutional dynamics shape the entrepreneurial propensity of academics in the university context. The study was motivated by the need for greater understanding of the micro-foundations of ... -
Microbial community dynamics of farmed Atlantic salmon gill microbiomes during amoebic gill disease episodes
(NUI Galway, 2022-06-14)Gill pathologies, especially the Amoebic Gill Disease (AGD), present one of the main health concerns for marine aquaculture worldwide. In Ireland alone, Atlantic salmon (Salmo salarL.) production in fish farms was 12,000 ... -
Microbial ecology of E.coli removal mechanisms and drinking water production in slow sand filters exposed to emerging contaminants
(NUI Galway, 2019-04-19)Slow sand filters (SSFs) are a water treatment technology which can produce high quality water through a combination of physical and the activity of their microbial community. SSFs are easy to operate and have and low ... -
Microbial ecology of methanogenic sludge granulation and its application in the reduction of selenate and selenite
(NUI Galway, 7-05-21)This thesis attempts to address some of the knowledge gaps in the literature around methanogenic granulation. Much existing research focuses on granulation of flocculent biomass up to the point at which satisfactory ...