Browsing University of Galway Theses by Title
Now showing items 1194-1213 of 2276
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An investigation of neuroanatomical contributions to cognitive deficits associated with psychotic illness: A 4 year longitudinal follow-up study
(2017-02-20)Introduction: In general, individuals who experience a first-episode of psychosis (FEP) display deficits on a wide range of neuropsychological tasks compared to psychiatrically healthy individuals (Bora et al., 2014). ... -
Investigation of pathogenic vibrio in Irish aquaculture
(NUI Galway, 2023-07-31)Vibrio parahaemolyticus, Vibrio vulnificus and Vibrio cholerae are marine pathogens that cause gastroenteritis in humans after the consumption of infected shellfish. Vibrio can cause devastating losses of oysters, shrimps ... -
Investigation of radon prevention and mitigation: from radon measurements to specification for soil depressurisation systems
(NUI Galway, 2020-01-27)Reduction of indoor radon concentration in buildings is considered to be an important public health issue, since radon was recognised as the leading cause of lung cancer after tobacco smoking by the World Health Organisation. ... -
An investigation of reading abilities and the impact of programmed instruction on reading outcomes in children with autism specrtum disorder
(NUI Galway, 2018-05-11)This thesis investigates reading abilities and programmed instruction, i.e., instruction that is scripted and sequenced, with explicit learning goals, based on the principles of Applied Behaviour Analysis, in children with ... -
Investigation of sexual dimorphism in an animal model of neuropathic pain: role of the endocannabinoid system
(NUI Galway, 2023-05-15)Although the presence of sexual dimorphism in the symptomatology of neuropathic pain is well-established, the neurobiology underlying sex differences in pain processing and modulation remains unclear. Gonadal hormones ... -
Investigation of T cell receptor and immunoglobulin repertoire through next generation sequencing data
(2017-08-08)The diversity of the immunological repertoire has long been a subject of research focus, providing important insights into the adaptive immune system. Rapid developments in next generation sequencing technologies ... -
Investigation of the central serotonergic system in the olfactory bulbectomized rat model of depression
(2017-11-10)Depression is a devastating heterogeneous disease that has a high lifetime prevalence. Despite over 50 years of research, the aetiology of depression is still largely undetermined but the improper functioning of the central ... -
An investigation of the contribution of centrosomal genes to schizophrenia and cognitive function
(NUI Galway, 2020-03-11)The centrosome is the key microtubule organising centre of animal somatic cells. Centrosomes play a crucial role in brain development, influencing cell shape, polarity, motility, and division. The older of the two barrel-shaped ... -
An investigation of the effects of thermal and nonthermal processing methods on Polyacetylenes from Apiaceae
(2012)Polyacetylenes are a group of phytochemicals that have attracted significant interest in recent years due to their range of potential health-promoting bioactivities however, little is known about the effects of food ... -
Investigation of the genetic basis of schizophrenia and cognitive function
(NUI Galway, 2019-01-25)Schizophrenia (SZ) is a chronic psychiatric disorder affecting approximately 1% of the population. Symptoms range from delusional thoughts and hallucinations to anhedonia and social withdrawal. Affected individuals also ... -
An investigation of the genetic contribution to cognitive resilience in healthy ageing
(NUI Galway, 2021-07)Cognitive decline is one of the most feared aspects of ageing leading to major health and social issues. Non-pathological or age-related cognitive decline leads to increased challenges in completing tasks that require ... -
An investigation of the immunometabolic interactions of obesity
(2013-09-04)Human monocytes are classified as classical, intermediate and non-classical according to their surface expression of CD14 and CD16. They also represent precursors to atherogenic foam cells and macrophages in metabolically ... -
Investigation of the mechanisms of repair following Ventilator Induced Lung Injury and the potential for Mesenchymal Stem Cells to enhance the repair process
(2012-02-10)Introduction: ARDS is a syndrome of acute respiratory failure that presents with progressive arterial hypoxemia, dyspnea, and a marked increase in the work of breathing. Virtually all patients with ARDS receive mechanical ... -
An investigation of the relationship between international law, international politics and the state using Syria as a case study
(NUI Galway, 2018-11-20)The thesis investigates the relationship between international law, international politics and the state using Syria as a case study. Syria was chosen because it has historically been the site of regional and international ... -
An investigation of the role of body-worn inertial sensing in the analysis of elite swimming performance
(2017-09-29)Swimming is a technically demanding sport that requires ongoing quantitative assessment in order to monitor technical progression and improvements in performance. Traditional methods of monitoring a swimmer’s technique ... -
Investigation of the role of mesenchymal stromal cells in modulating macrophage phenotype and function in the colorectal tumour microenvironment
(NUI Galway, 2022-06-28)Colorectal cancer (CRC) is the third most commonly occurring cancer. While there have been improvements in treatment options for patients, it remains the second leading cause of cancer-related deaths worldwide. CRC develops ... -
Investigation of the role of nuclear factor kappa-B in mediating the effects of hypercapnic acidosis and mesenchymal stem cells in ventilation induced lung injury
(NUI Galway, 2016-11-08)Introduction: ARDS is a syndrome of acute respiratory failure that presents with progressive arterial hypoxemia, dyspnea, and a marked increase in the work of breathing. Mechanical ventilation is necessary to support life ... -
An investigation of the role of the hypersialylated myeloma cell surface in facilitating evasion of natural killer cell-mediated immunosurveillance
(NUI Galway, 2021-12-30)Abnormal glycosylation is a hallmark of cancer, and hypersialylation in particular has been shown to facilitate abnormal cell trafficking and drug resistance in many cancers, including Multiple Myeloma (MM) - a currently ... -
Investigation of the Role of the NF-kB Pathway in Mediating the Effects of Hypercapnic Acidosis in Prolonged Systemic Sepsis and Ventilation Induced Acute Lung Injury
(2012-11)Background: Lung protective ventilation is integral to the management of ARDS. The resulting respiratory acidosis [HCA], termed 'permissive hypercapnia', is protective in diverse non-septic acute lung injury [ALI] models, ... -
Investigation of the structure and function of the metal transporter CzrB from Thermus thermophilus and the molecular chaperone trigger factor from Psychrobacter frigidicola by X-ray crystallography
(2014-09-26)A crystallographic approach was taken to investigate the structure and function of two proteins of interest previously isolated in our research group and identified as having potential application in improving the production ...