Browsing University of Galway Theses by Title
Now showing items 501-520 of 2276
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The Development of a Computational Test-Bed to Assess Coronary Stent Implantation
(2013-03-15)The implantation behaviour of coronary stents is of great interest to clinicians and engineers alike as in-stent restenosis (ISR) remains a critical issue with the community. ISR is hypothesized to occur for ... -
The development of a digital intervention to promote timely presentation of breast cancer symptoms to a healthcare professional
(NUI Galway, 2019-10-31)Breast cancer is the primary cause of death among women globally and in Ireland, mortality rates from breast cancer are the third highest in Europe. Early diagnosis of breast cancer is linked to more favourable outcomes ... -
Development of a dual-hit model of Parkinson's disease by combining environmental and genetic risk factors
(2012-06-06)Even though half a century has passed since the discovery of the efficacy of the dopamine precursor, levodopa, it remains the most effective therapy for the motor symptoms of Parkinson's disease to this day, despite its ... -
Development of a fundus camera with adaptive optics using a pyramid wavefront sensor
(2012-03-02)This PhD thesis presents the building of an adaptive-optics system based on a pyramid wavefront sensor applied to the imaging of the human retina (fundus) in vivo. The instrument aims to simultaneaously measure the ocular ... -
Development of a gene-eluting stent for the treatment of in-stent restenosis
(2016-05-12)In-stent restenosis (ISR) results from stent-induced arterial injury, characterized by a complex cascade of cellular and biochemical events. The removal of endothelium during an angioplasty procedure causes the underlying ... -
Development of a global energy management system for the non-energy intensive multi-site manufacturing organisations
(NUI Galway, 2018-09-30)Climate change and energy resource sustainability are both major challenges facing humanity today. Due to their scale, multi-site (and/or multi-national) manufacturing organisations (MMO), are large consumers of energy, ... -
Development of a high throughput screening strategy for drug discovery: from marine fungi to stem cell applications
(NUI Galway, 2021-08-04)Chemical compounds synthetized by living organisms have historically contributed to improved human health. Ancient populations made use of local natural products through herbal medicine, which today are to be found as ... -
Development of a high time resolution optical polarimeter for astronomy
(NUI Galway, 2018-12-17)This work started in September, 2014 and initially started as an investigation of the characterisation issues associated with using Electron Multiplying Charge- Coupled Devices (EMCCDs) in a two beam polarimeter. It was ... -
Development of a high-resolution gamma-ray imaging system with synthetic collimation.
(2013-11-01)This work outlines the development of a multi-pinhole single-photon emission computed tomography (SPECT) system designed to produce a synthetic-collimator image of a small field of view. The synthetic-collimator image was ... -
The development of a high-resolution nested bridge hydraulic model
(NUI Galway, 2023-11-23)Traditionally, hydraulic modelling of bridges has been undertaken using one dimensional models like HEC-RAS. One-dimensional models simplify river channels using several cross sections along a river curve and strongly ... -
Development of a mesenchymal stromal cell / collagen scaffold product for treatment of diabetic wounds
(NUI Galway, 2022-08-23)Foot ulceration is a major complication of diabetes mellitus, which results in significant human suffering and a major burden on healthcare systems. Mesenchymal stromal cells (MSCs) emerged as a promising therapeutic ... -
Development of a microgel-based cell delivery platform for critical limb ischemia
(2017-05-05)Peripheral Arterial Diseases (PAD) is a chronic and debilitating disease caused due to narrowing and hardening of arteries, that results in progressive deterioration of blood flow to the limbs. PAD commonly occurs in the ... -
Development of a mixed glial in vitro robust platform for therapeutic applications in spinal cord injury
(NUI Galway, 2021-06-30)Spinal cord injury (SCI) is a catastrophic event, and current strategies for SCI pose several limitations. One of the critical hallmarks of SCI is inflammation, which is due to the activation of microglia and astrocytes. ... -
Development of a nested 3D hydrodynamic model for tidal turbine impact assessment
(2016-05-12)Tidal current energy resources have the potential to provide a sizable proportion of our future energy requirements. However, significant questions still exist on the impacts of tidal turbines on the hydrodynamic environment. ... -
Development of a novel companion diagnostic for IRE1α activity and its application to investigate the role of IRE1α in acute myeloid leukaemia cells
(NUI Galway, 2020-08-28)The unfolded protein response (UPR) is an evolutionarily conserved mechanism activated in response to accumulation of unfolded protein (termed ER stress). Activation of the UPR is observed during many physiological processes ... -
Development of a novel water quality index model using data science approaches
(NUI Galway, 2023-05-30)The thesis present the Irish Water Quality Index (IEWQI) model for assessing transitional and coastal water quality in an effort to improve the method and develop a tool that can be used by environmental regulators to abate ... -
The development of a novel, pre-deployment resilience building programme for Irish defence forces personnel
(NUI Galway, 2022-06-27)Background: Military personnel are, by the nature of their profession, at an increased risk of exposure to potentially traumatic events. Military personnel are also exposed to chronic stress caused by work related factors ... -
Development of a Probabilistic Multi-Zone Multi-Source Computational Model for Indoor Air Pollution Exposure Assessment
(2014-02-12)Airborne Particulate Matter (PM) is a major environmental concern because of its known impacts on human health, and since the developed world population spends approximately 89% of its time indoors, PM in the indoor ... -
Development of a psychometric measure of physical post traumatic growth in prostate cancer and evaluation of its role in predicting psychological adjustment
(2015-01-30)Post traumatic growth (PTG) can be defined as positive change following a traumatic event (Tedeschi & Calhoun, 1995). The current conceptualisation of PTG encompasses five main dimensions: perceived changes in self; ... -
Development of a standardised assessment methodology relating to flexibility analysis for demand response
(NUI Galway, 2020-09-28)Power and energy flexibility in buildings and sites is an integral part of the solution to address the electrical grid’s challenges posed by increasing renewable generation, decarbonisation of the electricity supply and ...