Browsing University of Galway Theses by Title
Now showing items 1160-1179 of 2276
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Investigating the impact of genomic profiling on breast cancer risk prediction, treatment and outcome
(2018-02-05)It has, for many years, been acknowledged that “breast cancer” is an umbrella term for many genetically and immunophenotypically distinct malignancies of the breast. Treatment paradigms are shifting in direct response to ... -
Investigating the mechanism of action and potential efficacy of Apolipoprotein E mimetics as therapeutic agents for the treatment of metastatic prostate cancer
(2017-10-04)Prostate cancer is the most prevalent non cutaneous cancer diagnosed in Irish men and the third leading cause of death in males annually in Ireland. Therapeutic strategies currently consist of prostatectomy or radiation ... -
Investigating the potential of targeting the CB2 receptor for anti-inflammatory disease modification in Parkinson’s disease
(NUI Galway, 2021-10-22)Parkinson’s disease is a multifaceted neurodegenerative disorder that currently has no cure. Chronic neuroinflammation is thought to play a crucial role in the progression of the disease, with neuroinflammation and ... -
Investigating the role of amplified centrosomes in tumourigenesis of breast cancer
(NUI Galway, 2021-06-28)Centrosomes, the major microtubule organising centre (MTOC) of cell play essential roles in regulating cell cycle control, spindle assembly and genomic stability. Centrosome amplification (CA), a numerical centrosomal ... -
Investigating the role of IRE1α RNase activity in breast cancer
(NUI Galway, 2018-12-17)Metastatic, drug resistant disease poses the greatest threat to the survival of breast cancer patients. Thus, elucidating and targeting mechanisms which govern this phenotype is a primary goal of the breast cancer field. ... -
Investigating the role of the endogenous cannabinoid system in emotional modulation of pain: neurochemical and molecular mechanisms
(2012-03-24)Abstract Pain represents a major unmet clinical need and affects a large number of individuals worldwide. The modulation of pain by cognitive and emotional factors is now widely recognised. Increased understanding of the ... -
Investigating the roles of Chl1 helicase in DNA damage tolerance pathways
(NUI Galway, 2023-01-09)Faithful DNA replication is fundamental to ensure proper genomic stability. Eukaryotic cells have evolved sophisticated networks to deal with DNA lesions encountered during chromosome replication. The DNA damage response ... -
Investigating the roles of MARCKS and MARCKS-like 1 proteins in Xenopus laevis spinal cord development and regeneration
(NUI Galway, 2024-02-12)The identification and characterisation of key molecules that can promote or suppress regeneration has been an elusive, long-sought objective for researchers in spinal cord injury. The myristoylated alanine-rich C-kinase ... -
Investigating the Structural and Magnetic Characteristics of Polynuclear Complexes including the Solid-State Hosting Abilities of [M7] {M = Ni(II), Zn(II), Co(II/III)} Metallocalix[6]arene Discs.
(2012-11-02)We report the synthesis, structural and magnetic characterisation of a family of planar, pseudo metallocalix[6]arene disc-like complexes (1-10 and 14-21) of general formula [M7(OH)6(Lx)6](NO3)2 {M = Ni(II), Zn(II), Co(II/III)} ... -
Investigating the temporal and phase relations of oscillatory mechanisms involved in auditory binding
(NUI Galway, 2019-02-11)Abstract Introduction: Auditory binding refers to the integration of the components of a sound to form a wholistic percept. The present research explores similarities within visual and auditory binding mechanisms by testing ... -
Investigating the use of distributional semantic models for co-hyponym identification in special corpora
(2015-06-15)Knowledge is assumed by cognitive science to consist of concepts that are organised and maintained by complex processes taking place in human minds. These processes are not yet accessible directly. Language is still the ... -
Investigating the use of the Relational Evaluation Procedure (REP) in children
(2017-03-27)The core aim of this thesis was to explore the use of the Relational Evaluation Procedure (REP) in children, both typically developing, as well as developmentally delayed. The REP (e.g., Stewart, Barnes-Holmes & Roche, ... -
An investigation into computational modelling strategies to predict the in vitro performance of aortic valve replacements
(NUI Galway, 2023-06-19)The development and design of effective aortic valve replacements (AVRs) presents significant challenges given the structural and hemodynamic performance requirements that must be achieved. Conventional design approaches ... -
An investigation into how family support provided by Ireland’s Child and Family Agency is represented in Ireland’s print media
(NUI Galway, 2021-04-21)The aim of this thesis is to critically analyse how the media portray family support provided by the Child and Family Agency (Tusla) in Ireland. In phase one, a newspaper content analysis was conducted on a broad range ... -
An investigation into public stigma towards depression: measuring, predicting and reducing negative responses among adolescents
(2016-05-13)The current research focuses on how adolescents stigmatise their peers with depression and explores this theme in a series of three interrelated studies. Study 1 tests an empirical model of public stigma towards depression ... -
An investigation into the factors influencing venom potency in snakes and spiders
(NUI Galway, 2024-03-28)A fundamental question in ecology and toxicology is why some venomous species have more potent venoms than others. While there is great interest in venomous species from a medical perspective due to envenomation cases ... -
Investigation into the Influence of Temperature on the Cryopreservation of Mesenchymal Stem Cells
(2012-09-28)Mesenchymal Stem Cells (MSCs) are utilised in regenerative medicine due to their multilineage differentiation potential, ease of isolation, capacity for in vitro expansion and wide-spread availability in the adult tissues. ... -
Investigation into the prevalence and persistence of Listeria monocytogenes in Irish seafood: Possible roles for σB in environmental persistence
(2017-03-31)L. monocytogenes is a robust bacterial pathogen capable of surviving in a wide range of environments including food processing facilities. This pathogen is of concern for the food processing industry particularly producers ... -
An investigation into the role of fibre bridging as a toughening mechanism in engineered composite materials
(NUI Galway, 2022-06-27)Fibre reinforced composites are becoming increasingly popular in engineering design due to their high strength to weight ratio. In one of the failure mechanisms, which can occur during impact, fibres can bridge between ... -
An investigation into weight mediated conditions as risk factors for the development of autism spectrum disorder in offspring and the application of applied behavior analysis to pre-pregnancy weight behavior
(NUI Galway, 2018-09-03)Obesity (OB) has been identified as one of the greatest health concerns of the present time, due to the universally increasing rates (WHO, 2016). It has been found that a large proportion of the rise of OB is among women ...