Browsing University of Galway Theses by Title
Now showing items 1150-1169 of 2276
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The introduction of a legal framework for Advance Directives in Irish mental health care
(2014-06-03)Advance directives (ADs) are legal statements or documents, which allow a person to outline treatment preferences and other life choices prior to a mental health crisis. This thesis examines the issues arising in relation ... -
Invasive haemodynamic characteristics and clinical outcomes of patients presenting with symptomatic severe aortic valve stenosis undergoing transcatheter aortic valve implantation
(2016-01-12)The present thesis is comprised of an introduction followed by eight chapters. The introduction gives an overview of the transcatheter aortic valve implantation (TAVI) procedure and details the patient selection process. ... -
Inventing Liberia: imagining and representing colony and nation in American, Liberian and European writing 1820-1940
(NUI Galway, 2018-10-11)Liberia, the West African nation, whose name connotes freedom, was the creation of the American Colonisation Society (ACS) whose initial aim was to rid the United States of a growing population of ‘free people of colour.’ ... -
Inversion of magnetotelluric data in an anisotropic domain
(2014-02-10)The aim of this study was to develop a set of tools -- algorithms that would be translated into computer programs at a later stage -- to invert anisotropic magnetotelluric data within a framework that integrates ... -
Investigating Irish antiquarianism: A comparative study of Protestant and Catholic antiquarian cultures, 1830-1876
(2017-09-15)The aim of this study is to investigate the differences in and similarities between Protestant and Catholic antiquarian cultures in Ireland in the period 1830 to 1876. The thesis demonstrates that there were notable ... -
Investigating nucleolar dynamics in karyotypically normal human cells by fluorescent protein tagging of genes encoding key nucleolar proteins
(NUI Galway, 2022-06-14)The nucleolus, the site of ribosome biogenesis, is the largest membrane-less structure or organelle in the eukaryotic nucleus. It forms around arrays of ribosomal gene (rDNA) repeats termed nucleolar organizer regions ... -
Investigating sediment source, supply and evolution of the Northwest Carboniferous Basin: A multi-proxy provenance approach
(NUI Galway, 2022-06-14)Provenance analysis investigates the origin of sediment and its pathways into sedimentary basins. Such analysis must consider certain external controls (e.g. location and scale of the transportsystem feeding a basin, ... -
Investigating the effect of anti-inflammatory hyaluronic acid towards regenerating the annulus fibrosus
(2017-05-11)Neck and low-back pain are major causes of disability leading to a serious socio-economic burden worldwide. The pathology is strongly correlated with the intervertebral disc degeneration (IVD). Disc degenerative disease ... -
Investigating the epigenetic regulation of toll-like receptor 3
(2017-10-20)Toll-like receptors are a family of pattern recognition receptors (PRRs), which have evolved to recognise structurally conserved components of microorganisms. They form an important part of the innate immune system, yet ... -
Investigating the genetics of deep learning derived neuro imaging phenotypes of brain disorders
(NUI Galway, 2024-04-17)Brain disorders are collections of debilitating phenotypes that can affect cognition and general life quality via a myriad of symptoms, including mood swings, memory loss, altered thought processes, and psychosis. Despite ... -
Investigating the impact of genomic profiling on breast cancer risk prediction, treatment and outcome
(2018-02-05)It has, for many years, been acknowledged that “breast cancer” is an umbrella term for many genetically and immunophenotypically distinct malignancies of the breast. Treatment paradigms are shifting in direct response to ... -
Investigating the mechanism of action and potential efficacy of Apolipoprotein E mimetics as therapeutic agents for the treatment of metastatic prostate cancer
(2017-10-04)Prostate cancer is the most prevalent non cutaneous cancer diagnosed in Irish men and the third leading cause of death in males annually in Ireland. Therapeutic strategies currently consist of prostatectomy or radiation ... -
Investigating the potential of targeting the CB2 receptor for anti-inflammatory disease modification in Parkinson’s disease
(NUI Galway, 2021-10-22)Parkinson’s disease is a multifaceted neurodegenerative disorder that currently has no cure. Chronic neuroinflammation is thought to play a crucial role in the progression of the disease, with neuroinflammation and ... -
Investigating the role of amplified centrosomes in tumourigenesis of breast cancer
(NUI Galway, 2021-06-28)Centrosomes, the major microtubule organising centre (MTOC) of cell play essential roles in regulating cell cycle control, spindle assembly and genomic stability. Centrosome amplification (CA), a numerical centrosomal ... -
Investigating the role of IRE1α RNase activity in breast cancer
(NUI Galway, 2018-12-17)Metastatic, drug resistant disease poses the greatest threat to the survival of breast cancer patients. Thus, elucidating and targeting mechanisms which govern this phenotype is a primary goal of the breast cancer field. ... -
Investigating the role of the endogenous cannabinoid system in emotional modulation of pain: neurochemical and molecular mechanisms
(2012-03-24)Abstract Pain represents a major unmet clinical need and affects a large number of individuals worldwide. The modulation of pain by cognitive and emotional factors is now widely recognised. Increased understanding of the ... -
Investigating the roles of Chl1 helicase in DNA damage tolerance pathways
(NUI Galway, 2023-01-09)Faithful DNA replication is fundamental to ensure proper genomic stability. Eukaryotic cells have evolved sophisticated networks to deal with DNA lesions encountered during chromosome replication. The DNA damage response ... -
Investigating the roles of MARCKS and MARCKS-like 1 proteins in Xenopus laevis spinal cord development and regeneration
(NUI Galway, 2024-02-12)The identification and characterisation of key molecules that can promote or suppress regeneration has been an elusive, long-sought objective for researchers in spinal cord injury. The myristoylated alanine-rich C-kinase ... -
Investigating the Structural and Magnetic Characteristics of Polynuclear Complexes including the Solid-State Hosting Abilities of [M7] {M = Ni(II), Zn(II), Co(II/III)} Metallocalix[6]arene Discs.
(2012-11-02)We report the synthesis, structural and magnetic characterisation of a family of planar, pseudo metallocalix[6]arene disc-like complexes (1-10 and 14-21) of general formula [M7(OH)6(Lx)6](NO3)2 {M = Ni(II), Zn(II), Co(II/III)} ... -
Investigating the temporal and phase relations of oscillatory mechanisms involved in auditory binding
(NUI Galway, 2019-02-11)Abstract Introduction: Auditory binding refers to the integration of the components of a sound to form a wholistic percept. The present research explores similarities within visual and auditory binding mechanisms by testing ...