Browsing University of Galway Theses by Title
Now showing items 1027-1046 of 2276
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Identification and characterisation of germline variants in an Irish cohort with breast cancer
(NUI Galway, 2020-02-10)Breast cancer is the most common female malignancy worldwide, and the second most common cause of cancer-related deaths in women. Twin studies estimate that up to one third of breast cancers are the result of hereditary ... -
Identification and characterisation of novel glycan-binding bacterial adhesins encoded by the human gut microbial metagenome
(2017-03-24)Although there have been an increasing number of scientific publications describing the adherence of gut bacteria to components of the human intestinal mucosa, very little is known about the surface molecules mediating ... -
Identification and validation of novel targets of regulated IRE1-dependent decay in triple negative breast cancer
(NUI Galway, 2023-08-16)Breast cancer is the most commonly diagnosed cancer in women. Triple-negative breast cancer (TNBC) refers to a subtype which lacks oestrogen receptors (ESR1), progesterone receptors (PR) and does not overexpress Human ... -
Identification of bioactive natural products after screening Irish marine bio-resources
(2016-10-21)According to the “Real Map of Ireland” published by Marine Institute, Ireland, the Nation marine territory has ten times more area than its land mass. Despite the well-studied and reported biodiversity present in Irish ... -
Identification of compounds that may be repurposed for the treatment of triple negative breast cancer
(2012-11-21)Triple negative breast cancers (TNBC), lack the estrogen and progesterone receptors as well as the HER2 receptor. Currently, there is no selective therapy for the treatment of TNBC and current treatment regimens rely on a ... -
Identification of decisive molecular interactions regulating resistance to apoptosis in tumour cells
(14-07-04)TRAIL is a member of the TNF family of cytokines which can selectively induce apoptosis in cancerous cells. For this reason recombinant TRAIL is being considered for the treatment of cancer. During their development cancer ... -
Identification of growth limiting factors in Synechocystis sp. PCC 6803
(2018-02-15)In this study we showed that Synechocystis sp. PCC 6803 can achieve fast division rates using urea, a low-cost nitrogen source that does not require energy for uptake and hydrolysis, and releases CO2 into to the cell during ... -
Identification of IRS4 and TOP2A as novel CDC7 kinase interacting proteins
(2016-02-08)CDC7 is an essential serine/threonine kinase required for the initiation of DNA replication in eukaryotic cells, through phosphorylating the MCM helicase complex. Formation of an active kinase requires the binding to ... -
Identification of novel drug combinations for haematological malignancies
(2015-01-29)TNF-related apoptosis ligand (TRAIL) is a tumour selective cytokine with potential anti-cancer activity which is currently in clinical trials. Haematological malignancies along with several other cancers have showed varied ... -
Identification of novel factors that promote trinucleotide repeat instability
(2013-09-23)Trinucleotide repeat (TNR) expansions are the genetic cause of several inherited neurological diseases. Factors that affect the propensity of TNRs to expand include the characteristics of the TNR DNA, the chromatin ... -
Identification of plant-specific components of the Polycomb Group pathway and their roles in the regulation of Arabidopsis thaliana development
(NUI Galway, 2019-09-30)The knowledge about Arabidopsis thaliana developmental life cycle is deep in broad strokes. Nevertheless, the mechanisms that fine tune these phase transitions are still poorly described. One of these mechanisms is the ... -
Identification of prognostic targets in breast cancer using immunohistochemical and in situ hybridisation methodologies
(2011-12-16)Advances in our understanding of the molecular mechanisms underlying breast cancer are leading to improvements in its management. Many of the recent gene-based signatures developed for breast cancer have highlighted the ... -
Identifying novel drug therapies for acute myeloid leukaemia by targeting the interactions between leukaemia cells and bone marrow microenvironment
(NUI Galway, 2019-10-25)Acute myeloid leukaemia (AML) is a malignancy caused by a block in differentiation in which aberrant leukemic stem cells drive the production of undifferentiated or partially differentiated leukemic blast cell clones. ... -
Identifying novel strategies to re-engage the apoptotic pathway for the treatment of cancer
(2014-09-30)In chapter two we demonstrate that in non-transformed cells multiple signalling pathways control TRAIL resistance and they act in a redundant manner. This is contrary, however, to the resistance mechanisms found in tumour ... -
Identifying, annotating, and filtering arguments and opinions in open collaboration systems
(2013-09-13)The World Wide Web enables large-scale collaboration, even between groups of individuals previously unknown to one another. These collaborations produce tangible outputs, such as encyclopedias (Wikipedia), electronic books ... -
Identity Formation Among Teenaged Members of the Muslim Population of Ballyhaunis, Co. Mayo
(2012-08-29)Younger members of Muslim populations in Western society are placed at the frontline of the immigration process. As a result of daily school attendance and exposure to the media they are often heavily influenced by the ... -
Illegal territoriality in international law: the interaction and enforcement of the law of belligerant occupation through other territorial regimes
(2014-08-30)This work examines the place and function of the international law of belligerent occupation its interplays with other public international law regimes and argues that the co-application of these regimes, as well as an ... -
(Im)Possibility of Utopia: Aldous Huxley and Michel Houellebecq
(NUI Galway, 2023-08-17)This thesis examines the connections between ambivalence and Utopianism through the writings of Aldous Huxley and Michel Houellebecq. By conducting a comprehensive analysis of the authors’ seminal works, this study ... -
Image and video quality in the automotive environment
(2016-05-12)This thesis is concerned with the development of methodologies for image and video quality assessment for the automotive environment, and the use of those methodologies for evaluating the effect of image and video ... -
Image super-resolution for consumer thermal cameras
(NUI Galway, 2019-01-21)This thesis attempts to solve a problem currently faced by consumer-grade thermal cameras. Consumers have grown accustomed to the high pixel counts and high resolution offered by the modern smartphone, while the performance ...