Now showing items 1-7 of 7

  • Generation of rationally-designed nerve growth factor (NGF) variants with receptor specificity 

    Carleton, Laura A.; Chakravarthy, Reka; van der Sloot, Almer M.; Mnich, Katarzyna; Serrano, Luis; Samali, Afshin; Gorman, Adrienne M. (Elsevier, 2017-11-03)
    Nerve growth factor (NGF) is the prototypic member of the neurotrophin family and binds two receptors, TrkA and the 75 kDa neurotrophin receptor (p75NTR), through which diverse and sometimes opposing effects are mediated. ...
  • The integrated stress response 

    Pakos-Zebrucka, Karolina; Koryga, Izabela; Mnich, Katarzyna; Ljujic, Mila; Samali, Afshin; Gorman, Adrienne M. (EMBO Press, 2016-09-14)
    In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway, termed the integrated stress response (ISR), to restore cellular homeostasis. The core event in this pathway is the phosphorylation ...
  • Nerve growth factor (NGF)-mediated regulation of p75(NTR) expression contributes to chemotherapeutic resistance in triple negative breast cancer cells 

    Chakravarthy, Reka; Mnich, Katarzyna; Gorman, Adrienne M. (Elsevier, 2016)
    Triple negative breast cancer [TNBC] cells are reported to secrete the neurotrophin nerve growth factor [NGF] and express its receptors, p75 neurotrophin receptor [p75(NTR)] and TrkA, leading to NGF-activated pro-survival ...
  • Nerve Growth Factor in Cancer Cell Death and Survival 

    Molloy, Niamh H.; Read, Danielle E.; Gorman, Adrienne M. (MDPI, 2011-02)
    One of the major challenges for cancer therapeutics is the resistance of many tumor cells to induction of cell death due to pro-survival signaling in the cancer cells. Here we review the growing literature which shows that ...
  • RIP2 enhances cell survival by activation of NF-ĸB in triple negative breast cancer cells 

    Jaafar, Rola; Mnich, Katarzyna; Dolan, Sarah; Hillis, Jennifer; Almanza, Aitor; Logue, Susan E.; Samali, Afshin; Gorman, Adrienne M. (Elsevier, 2018-02-06)
    Receptor-interacting protein 2 (RIP2) is an essential mediator of inflammation and innate immunity, but little is known about its role outside the immune system. Recently, RIP2 has been linked to chemoresistance of triple ...
  • Role of mitochondria in neuronal apoptosis 

    Gorman, Adrienne M.; Ceccatelli, Sandra; Orrenius, Sten (Karger Publishers, 2000-12)
    Apoptosis is a controlled form of cell death that participates in the demise of neuronal cells during development, neurodegenerative disorders and exposure to neurotoxic agents. In recent years, the mitochondria have emerged ...
  • Stress management at the ER: regulators of ER stress-induced apoptosis. 

    Gorman, Adrienne M.; Healy, Sandra J.M.; Jäger, Richard; Samali, Afshin (Elsevier, 2012-02-17)
    The endoplasmic reticulum (ER) is an elaborate cellular organelle essential for cell function and survival. Conditions that interfere with ER function lead to the accumulation and aggregation of unfolded proteins which are ...